A global view of the genetic basis of Alzheimer disease

C Reitz, MA Pericak-Vance, T Foroud… - Nature Reviews …, 2023 - nature.com
The risk of Alzheimer disease (AD) increases with age, family history and informative genetic
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …

Protective genes and pathways in Alzheimer's disease: moving towards precision interventions

M Seto, RL Weiner, L Dumitrescu… - Molecular …, 2021 - Springer
Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that is characterized
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …

The links between cardiovascular diseases and Alzheimer's disease

J Leszek, EV Mikhaylenko, DM Belousov… - Current …, 2021 - ingentaconnect.com
The root cause of non-inherited Alzheimer's disease (AD) remains unknown despite
hundreds of research studies performed to attempt to solve this problem. Since proper …

Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier

K Kisler, AP Sagare, D Lazic, S Bazzi, E Lawson… - Molecular …, 2023 - Springer
Background PICALM is one of the most significant susceptibility factors for Alzheimer's
disease (AD). In humans and mice, PICALM is highly expressed in brain endothelium …

Endosomal trafficking and related genetic underpinnings as a hub in Alzheimer's disease

A Limone, I Veneruso, V D'Argenio… - Journal of Cellular …, 2022 - Wiley Online Library
Genetic studies support the amyloid cascade as the leading hypothesis for the pathogenesis
of Alzheimer's disease (AD). Although significant efforts have been made in untangling the …

PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity

Y Yu, T Niccoli, Z Ren, NS Woodling… - Human molecular …, 2020 - academic.oup.com
Alzheimer's disease (AD) is the most common form of dementia and the most prevalent
neurodegenerative disease. Genome-wide association studies have linked PICALM to AD …

Alzheimer's Disease in Lebanon: Exploring Genetic and Environmental Risk Factors—A Comprehensive Review

M Khaled, H Al-Jamal, L Tajer… - Journal of Alzheimer's …, 2024 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative condition that displays a high prevalence
in Lebanon causing a local burden in healthcare and socio-economic sectors. Unfortunately …

[HTML][HTML] Association of immunity-related gene SNPs with Alzheimer's disease

N Bissar, R Kassir, A Salami… - … Biology and Medicine, 2024 - pmc.ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by
progressive cognitive decline. Genetic factors have been implicated in disease susceptibility …

Machine Learning Approach to Identify Case-Control Studies on ApoE Gene Mutations Linked to Alzheimer's Disease in Italy

GF Saraceno, DM Abrego-Guandique, R Cannataro… - …, 2024 - mdpi.com
Background: An application of artificial intelligence is machine learning, which allows
computer programs to learn and create data. Methods: In this work, we aimed to evaluate the …

Using multi-omic approaches to identify modulators of Alzheimer's disease risk

M Seto - 2022 - search.proquest.com
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by
neurodegeneration, memory loss and cognitive impairment. Sporadic late-onset AD is the …