It has been a century since the death of Élie Metchnikoff, who championed the role of
phagocytosis in cellular immunity. Whereas others had observed the uptake of particles by …

Scavenger receptors belong to a superfamily of proteins that are structurally heterogeneous
and encompass the miscellaneous group of transmembrane proteins and soluble secretory …

Scavenger receptors were originally identified by their ability to recognize and to remove
modified lipoproteins; however, it is now appreciated that they carry out a striking range of …

Innate immunity is a rapidly evolving field with novel cell types and molecular pathways
being discovered and paradigms changing continuously. Innate and adaptive immune …

Endogenous mechanisms that orchestrate resolution of acute inflammation are essential in
host defense and the return to homeostasis. Resolvin (Rv) D2 is a potent immunoresolvent …

The induction of type I interferons by the bacterial secondary messengers cyclic di-GMP (c-di-
GMP) or cyclic di-AMP (c-di-AMP) is dependent on a signaling axis that involves the adaptor …

Mycobacterium tuberculosis thrives within macrophages by residing in phagosomes and
preventing them from maturing and fusing with lysosomes. A parallel transcriptional survey …

Phagocytes are crucial for host defense against bacterial pathogens. As first demonstrated
by Metchnikoff, neutrophils and mononuclear phagocytes share the capacity to engulf, kill …

Intracellular bacterial pathogens cause a wide range of diseases and significantly contribute
to the morbidity and mortality associated with infectious diseases worldwide (1‐16)(Table 1) …

Biological cellular systems are groups of cells sharing a set of characteristics, mainly key
function and origin. Phagocytes are crucial in the host defense against microbial infection …