Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged
pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus …
pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus …
Engineered living materials for sustainability
Recent advances in synthetic biology and materials science have given rise to a new form of
materials, namely engineered living materials (ELMs), which are composed of living matter …
materials, namely engineered living materials (ELMs), which are composed of living matter …
Efficient evolution of human antibodies from general protein language models
Natural evolution must explore a vast landscape of possible sequences for desirable yet
rare mutations, suggesting that learning from natural evolutionary strategies could guide …
rare mutations, suggesting that learning from natural evolutionary strategies could guide …
Broadly neutralizing antibodies target the coronavirus fusion peptide
The potential for future coronavirus outbreaks highlights the need to broadly target this
group of pathogens. We used an epitope-agnostic approach to identify six monoclonal …
group of pathogens. We used an epitope-agnostic approach to identify six monoclonal …
In vivo hypermutation and continuous evolution
Directed evolution has revolutionized biomolecular engineering by applying cycles of
mutation, amplification and selection to genes of interest (GOIs). However, classical directed …
mutation, amplification and selection to genes of interest (GOIs). However, classical directed …
Protein design and variant prediction using autoregressive generative models
JE Shin, AJ Riesselman, AW Kollasch… - Nature …, 2021 - nature.com
The ability to design functional sequences and predict effects of variation is central to protein
engineering and biotherapeutics. State-of-art computational methods rely on models that …
engineering and biotherapeutics. State-of-art computational methods rely on models that …
Machine learning for functional protein design
Recent breakthroughs in AI coupled with the rapid accumulation of protein sequence and
structure data have radically transformed computational protein design. New methods …
structure data have radically transformed computational protein design. New methods …
Engineered bacterial orthogonal DNA replication system for continuous evolution
R Tian, R Zhao, H Guo, K Yan, C Wang, C Lu… - Nature Chemical …, 2023 - nature.com
Continuous evolution can generate biomolecules for synthetic biology and enable
evolutionary investigation. The orthogonal DNA replication system (OrthoRep) in yeast can …
evolutionary investigation. The orthogonal DNA replication system (OrthoRep) in yeast can …
Discovery of VH domains that allosterically inhibit ENPP1
PE Solomon, CJ Bracken, JA Carozza, H Wang… - Nature chemical …, 2024 - nature.com
Abstract Ectodomain phosphatase/phosphodiesterase-1 (ENPP1) is overexpressed on
cancer cells and functions as an innate immune checkpoint by hydrolyzing extracellular …
cancer cells and functions as an innate immune checkpoint by hydrolyzing extracellular …
Programmable protein circuit design
Z Chen, MB Elowitz - Cell, 2021 - cell.com
A fundamental challenge in synthetic biology is to create molecular circuits that can program
complex cellular functions. Because proteins can bind, cleave, and chemically modify one …
complex cellular functions. Because proteins can bind, cleave, and chemically modify one …