Allosteric modulation of GPCRs has initiated a new era of basic and translational discovery,
filled with therapeutic promise yet fraught with caveats. Allosteric ligands stabilize unique …

Animals synchronize to the environmental day-night cycle by means of an internal circadian
clock in the brain. In mammals, this timekeeping mechanism is housed in the …

An important factor in reducing variability in mouse test outcomes has been to develop
assays that can be used for continuous automated home cage assessment. Our experience …

Sleep and circadian disorders in Alzheimer's disease (AD) are more frequent than in the
general population and appear early in the course of the disease. Quality of sleep and …

Dysfunction of the glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptor GluA1 subunit and deficits in synaptic plasticity are implicated in schizophrenia and …

Background: Disruption of rhythms in activity and rest occur in many diseases, and provide
an important indicator of healthy physiology and behaviour. However, outside the field of …

Membrane trafficking processes regulate G protein–coupled receptor (GPCR) activity.
Although class A GPCRs are capable of activating G proteins in a monomeric form, they can …

Schizophrenia is a multifactorial disorder caused by a combination of genetic variations and
exposure to environmental insults. Sleep and circadian rhythm disturbances are a prominent …

Previous preclinical work has demonstrated the therapeutic potential of antagonists of the
group II metabotropic glutamate receptors (mGlus). Still, compounds that are selective for the …

Circadian rhythms are approximately 24 h cycles in physiology and behaviour that enable
organisms to anticipate predictable rhythmic changes in their environment. These rhythms …