Understanding complex systems often requires a bottom-up analysis towards a systems
biology approach. The need to investigate a system, not only as individual components but …

Knowing the set of physical protein–protein interactions (PPIs) that occur in a particular
context—a tissue, disease, or other condition—can provide valuable insights into key …

In order to understand how a cancer cell is functionally different from a normal cell it is
necessary to assess the complex network of pathways involving gene regulation, signaling …

Germinal centers (GCs) support high-affinity, long-lived humoral immunity. How memory B
cells develop in GCs is not clear. Through the use of a cell-cycle-reporting system, we …

Assembly of a transcriptional and post‐translational molecular interaction network in B cells,
the human B‐cell interactome (HBCI), reveals a hierarchical, transcriptional control module …

Improved bioassays have significantly increased the rate of identifying new protein-protein
interactions (PPIs), and the number of detected human PPIs has greatly exceeded early …

The computational identification of oncogenic lesions is still a key open problem in cancer
biology. Although several methods have been proposed, they fail to model how such events …

The synergism between c-MYC and miR-17-19b, a truncated version of the miR-17-92
cluster, is well-documented during tumor initiation. However, little is known about miR-17 …

Alzheimer's disease (AD) and most of the other tauopathies are incurable
neurodegenerative diseases with unpleasant symptoms and consequences. The common …

This book is designed to introduce biologists, clinicians and computational researchers to
fundamental data analysis principles, techniques and tools for supporting the discovery of …