Homologous recombination enables the cell to access and copy intact DNA sequence
information in trans, particularly to repair DNA damage affecting both strands of the double …

Eukaryotic cells possess several mechanisms for repairing double-stranded breaks in DNA.
One mechanism involves genetic recombination with an intact sister duplex. The recent …

The human testis Rad51 protein, a structural homolog of E. coli RecA, binds single-and
double-stranded DNA and exhibits DNA-dependent ATPase activity. Using circular ssDNA …

▪ Abstract The primary function of bacterial recombination systems is the nonmutagenic
repair of stalled or collapsed replication forks. The RecA protein plays a central role in these …

RecA and its homologs help maintain genomic integrity through recombination. Using single-
molecule fluorescence assays and hidden Markov modeling, we show the most direct …

The recombinases of the RecA family are often viewed only as DNA-pairing proteins—they
bind to one DNA segment, align it with homologous sequences in another DNA segment …

In bacteria, the major function of homologous genetic recombination is re-combinational
DNA repair. This is not a process reserved only for rare double-strand breaks caused by …

▪ Abstract The bacterial RecA protein plays a central role in the repair of stalled replication
forks, double-strand break repair, general recombination, induction of the SOS response …

RecA protein filaments formed on circular (ssDNA) in the presence of ssDNA binding protein
(SSB) are generally stable as long as ATP is regenerated. On linear ssDNA, stable RecA …

Replication forks are halted by many types of DNA damage. At the site of a leading-strand
DNA lesion, forks may stall and leave the lesion in a single-strand gap. Fork regression is …