Accelerating antiviral drug discovery: lessons from COVID-19
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and
collaborative drug discovery efforts took place in academia and industry, culminating in …
collaborative drug discovery efforts took place in academia and industry, culminating in …
Roles of host proteases in the entry of SARS-CoV-2
A Zabiegala, Y Kim, KO Chang - Animal Diseases, 2023 - Springer
The spike protein (S) of SARS-CoV-2 is responsible for viral attachment and entry, thus a
major factor for host susceptibility, tissue tropism, virulence and pathogenicity. The S is …
major factor for host susceptibility, tissue tropism, virulence and pathogenicity. The S is …
In vitro and in vivo characterization of SARS-CoV-2 strains resistant to nirmatrelvir
M Kiso, Y Furusawa, R Uraki, M Imai… - Nature …, 2023 - nature.com
Nirmatrelvir, an oral antiviral agent that targets a SARS-CoV-2 main protease (3CLpro), is
clinically useful against infection with SARS-CoV-2 including its omicron variants. Since …
clinically useful against infection with SARS-CoV-2 including its omicron variants. Since …
Replication and single-cycle delivery of SARS-CoV-2 replicons
Molecular virology tools are critical for basic studies of the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and for developing new therapeutics. Experimental …
syndrome coronavirus 2 (SARS-CoV-2) and for developing new therapeutics. Experimental …
Small-molecule thioesters as SARS-CoV-2 main protease inhibitors: enzyme inhibition, structure–activity relationships, antiviral activity, and X-ray structure …
T Pillaiyar, P Flury, N Krüger, H Su… - Journal of Medicinal …, 2022 - ACS Publications
The main protease (Mpro, 3CLpro) of SARS-CoV-2 is an attractive target in coronaviruses
because of its crucial involvement in viral replication and transcription. Here, we report on …
because of its crucial involvement in viral replication and transcription. Here, we report on …
Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to be a
serious global public health threat. The 3C-like protease (3CLpro) is a virus protease …
serious global public health threat. The 3C-like protease (3CLpro) is a virus protease …
In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects …
Y Furusawa, M Kiso, S Iida, R Uraki, Y Hirata, M Imai… - …, 2023 - thelancet.com
Summary Background The SARS-CoV-2 delta (B. 1.617. 2 lineage) variant was first
identified at the end of 2020 and possessed two unique amino acid substitutions in its spike …
identified at the end of 2020 and possessed two unique amino acid substitutions in its spike …
Structure-guided design of potent spirocyclic inhibitors of severe acute respiratory syndrome coronavirus-2 3C-like protease
CS Dampalla, AD Rathnayake… - Journal of medicinal …, 2022 - ACS Publications
The worldwide impact of the ongoing COVID-19 pandemic on public health has made
imperative the discovery and development of direct-acting antivirals aimed at targeting viral …
imperative the discovery and development of direct-acting antivirals aimed at targeting viral …
Reverse genetic systems of SARS-CoV-2 for antiviral research
Reverse genetic systems are widely used to engineer recombinant viruses with desired
mutations. In response to the COVID-19 pandemic, four types of reverse genetic systems …
mutations. In response to the COVID-19 pandemic, four types of reverse genetic systems …
Marine natural products as leads against SARS-CoV-2 infection
BK Chhetri, PR Tedbury… - Journal of natural …, 2022 - ACS Publications
Since early 2020, disease caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has become a global pandemic, causing millions of infections and deaths …
(SARS-CoV-2) has become a global pandemic, causing millions of infections and deaths …