G-quadruplexes, intricate four-stranded structures composed of G-tetrads formed by four
guanine bases, are prevalent in both DNA and RNA. Notably, these structures play pivotal …

Abstract G-quadruplex (G4) structures formed by guanine-rich nucleic acids are implicated
in essential physiological and pathological processes and serve as important drug targets …

Connexins (Cx) are members of a protein family that forms intercellular channels localised in
gap junction (GJ) plaques and single transmembrane channels called hemichannels. They …

G-quadruplexes (G4) are non-canonical DNA structures found in the genome of most
species including human. Small molecules stabilizing these structures, called G4 ligands …

R-loops are a major source of genome instability associated with transcription-induced
replication stress. However, how R-loops inherently impact replication fork progression is …

Mature B cells notably diversify immunoglobulin (Ig) production through class switch
recombination (CSR), allowing the junction of distant “switch”(S) regions. CSR is initiated by …

G-quadruplexes are four-stranded helical nucleic acid structures formed by guanine-rich
sequences. A considerable number of studies have revealed that these noncanonical …

Non-canonical, four-stranded nucleic acids secondary structures are present within
regulatory regions in the human genome and transcriptome. To date, these quadruplex …

The thermal stability of G-quadruplexes is important for their biological roles. G-
quadruplexes are stable in the presence of cations such as K+ and Na+ because these …

Glaucoma is a heterogenous, chronic, progressive group of eye diseases, which results in
irreversible loss of vision. There are several types of glaucoma, whereas the primary open …