Multidrug resistance (MDR) is the dominant challenge in the failure of chemotherapy in
cancers. Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that spreads intracellular …

Cancer cell possesses numerous adaptations to resist the immune system response and
chemotherapy. One of the most significant properties of the neoplastic cells is the altered …

Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide, with high
recurrence and mortality rate. Chemotherapy, including 5-fluorouracil (5-FU), adriamycin …

Progesterone and its synthetic analogues, progestins, participate in the regulation of cell
differentiation, proliferation and cell cycle progression. Progestins are usually applied for …

Limited chemotherapeutic efficiency, drug resistance, and side effects are primary obstacles
for cancer treatment. The development of co-delivery systems with synergistic treatment …

Glioma, originating from neuroglial progenitor cells, is a type of intrinsic brain tumor with
poor prognosis. temozolomide (TMZ) is the first-line chemotherapeutic agent for glioma …

The incidence and mortality of colorectal cancer (CRC) have always been among the
highest in the world, although the diagnosis and treatment are becoming more and more …

The Wnt/β-catenin pathway is abnormally activated in most lung cancer tissues and
considered to be an accelerator of carcinogenesis and lung cancer progression, which is …

Background Cholangiocarcinoma (CCA) is a highly lethal cancer originated in the biliary
tree. Available treatments for CCA are scarcely effective, partly due to mechanisms of …

Due to advances in chip and sequencing technology, several types and numbers of long
non-coding RNAs (lncRNAs) have been identified. LncRNAs are defined as non-protein …