Small molecule metabolites: discovery of biomarkers and therapeutic targets
S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
Cirrhosis-associated immune dysfunction
A Albillos, R Martin-Mateos, S Van der Merwe… - Nature Reviews …, 2022 - nature.com
The term cirrhosis-associated immune dysfunction (CAID) comprises the distinctive
spectrum of immune alterations associated with the course of end-stage liver disease …
spectrum of immune alterations associated with the course of end-stage liver disease …
Acute-on-chronic liver failure clinical guidelines
In patients with cirrhosis and chronic liver disease, acute-on-chronic liver failure is emerging
as a major cause of mortality. These guidelines indicate the preferred approach to the …
as a major cause of mortality. These guidelines indicate the preferred approach to the …
[HTML][HTML] The systemic inflammation hypothesis: towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis
Acute decompensation (AD) of cirrhosis is defined by the development of ascites, hepatic
encephalopathy (HE) and/or variceal bleeding. Ascites is traditionally attributed to …
encephalopathy (HE) and/or variceal bleeding. Ascites is traditionally attributed to …
[HTML][HTML] The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology
Background & Aims Acute decompensation (AD) of cirrhosis is defined as the acute
development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or …
development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or …
[HTML][HTML] PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
Background & Aims Acute decompensation (AD) of cirrhosis may present without acute-on-
chronic liver failure (ACLF)(AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure …
chronic liver failure (ACLF)(AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure …
Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure
The human gut microbiome has emerged as a major player in human health and disease.
The liver, as the first organ to encounter microbial products that cross the gut epithelial …
The liver, as the first organ to encounter microbial products that cross the gut epithelial …
Liver transplantation for patients with acute-on-chronic liver failure (ACLF) in Europe: results of the ELITA/EF-CLIF collaborative study (ECLIS)
LS Belli, C Duvoux, T Artzner, W Bernal, S Conti… - Journal of …, 2021 - Elsevier
Background & Aims Liver transplantation (LT) has been proposed as an effective salvage
therapy even for the sickest patients with acute-on-chronic liver failure (ACLF). This large …
therapy even for the sickest patients with acute-on-chronic liver failure (ACLF). This large …
Acute-on-chronic liver failure
Acute-on-Chronic Liver Failure Acute decompensation in patients with chronic liver disease
is called acute-on-chronic liver failure. Usually, systemic inflammation from infection or an …
is called acute-on-chronic liver failure. Usually, systemic inflammation from infection or an …
Albumin in decompensated cirrhosis: new concepts and perspectives
The pathophysiological background of decompensated cirrhosis is characterised by a
systemic proinflammatory and pro-oxidant milieu that plays a major role in the development …
systemic proinflammatory and pro-oxidant milieu that plays a major role in the development …