[HTML][HTML] Small extracellular vesicles isolation and separation: Current techniques, pending questions and clinical applications

Y Jia, L Yu, T Ma, W Xu, H Qian, Y Sun, H Shi - Theranostics, 2022 - ncbi.nlm.nih.gov
Extracellular vesicles, especially small extracellular vesicles (sEVs) are now accepted as
important messengers in cell-to-cell communication and as a promising drug delivery …

Immune cells-derived exosomes function as a double-edged sword: role in disease progression and their therapeutic applications

A Hazrati, S Soudi, K Malekpour, M Mahmoudi… - Biomarker …, 2022 - Springer
Exosomes, ranging in size from 30 to 150 nm as identified initially via electron microscopy in
1946, are one of the extracellular vesicles (EVs) produced by many cells and have been the …

Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

E Dai, L Han, J Liu, Y Xie, G Kroemer, DJ Klionsky… - Autophagy, 2020 - Taylor & Francis
ABSTRACT KRAS is the most frequently mutated oncogene in human neoplasia. Despite a
large investment to understand the effects of KRAS mutation in cancer cells, the direct effects …

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

PUC Dinh, D Paudel, H Brochu, KD Popowski… - Nature …, 2020 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in
which persistent injury results in scar tissue formation. As fibrosis thickens, the lung tissue …

Engineered exosomes for studies in tumor immunology

A Alptekin, M Parvin, HI Chowdhury… - Immunological …, 2022 - Wiley Online Library
Exosomes are a type of extracellular vesicle (EV) with diameters of 30–150 nm secreted by
most of the cells into the extracellular spaces and can alter the microenvironment through …

Extracellular vesicles: delivery vehicles of myokines

E Trovato, V Di Felice, R Barone - Frontiers in physiology, 2019 - frontiersin.org
Movement and regular physical activity are two important factors that help the human body
prevent, reduce and treat different chronic diseases such as obesity, type 2 diabetes, heart …

Chimeric nanocomposites for the rapid and simple isolation of urinary extracellular vesicles

TNT Dao, MG Kim, B Koo, H Liu… - Journal of …, 2022 - Wiley Online Library
Cancer cell‐derived extracellular vesicles (EVs) are promising biomarkers for cancer
diagnosis and prognosis. However, the lack of rapid and sensitive isolation techniques to …

The roles of exosomes as future therapeutic agents and diagnostic tools for glioma

X Wu, X Wang, J Wang, Y Hao, F Liu, X Wang… - Frontiers in …, 2021 - frontiersin.org
Glioma is a common type of tumor originating in the brain. Glioma develops in the gluey
supporting cells (glial cells) that surround and support nerve cells. Exosomes are …

Bone marrow mesenchymal stem cells-derived exosomes improve injury of hippocampal neurons in rats with depression by upregulating microRNA-26a expression

H Guo, B Huang, Y Wang, Y Zhang, Q Ma… - International …, 2020 - Elsevier
Objective Bone marrow mesenchymal stem cells (BMSCs)-derived exosomes have been
widely applied in disease therapies. However, the role of BMSCs-derived exosomes in …

Most recent advances and applications of extracellular vesicles in tackling neurological challenges

M Kaur, S Fusco, B Van den Broek… - Medicinal Research …, 2024 - Wiley Online Library
Over the past few decades, there has been a notable increase in the global burden of
central nervous system (CNS) diseases. Despite advances in technology and therapeutic …