The JAK-STAT pathway at 30: Much learned, much more to do

RL Philips, Y Wang, HJ Cheon, Y Kanno, M Gadina… - Cell, 2022 - cell.com
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …

IL-6 in inflammation, autoimmunity and cancer

T Hirano - International immunology, 2021 - academic.oup.com
IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

Strategies to therapeutically modulate cytokine action

WJ Leonard, JX Lin - Nature Reviews Drug Discovery, 2023 - nature.com
Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …

The multifaced role of STAT3 in cancer and its implication for anticancer therapy

M Tolomeo, A Cascio - International journal of molecular sciences, 2021 - mdpi.com
Signal transducer and activator of transcription (STAT) 3 is one of the most complex
regulators of transcription. Constitutive activation of STAT3 has been reported in many types …

Cytokines in cancer immunotherapy

TA Waldmann - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
Cytokines that control the immune response were shown to have efficacy in preclinical
murine cancer models. Interferon (IFN)-α is approved for treatment of hairy cell leukemia …

Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy

W Liao, JX Lin, WJ Leonard - Immunity, 2013 - cell.com
Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays
pivotal roles in the immune response. Discovered as a T cell growth factor, IL-2 additionally …

JAKs and STATs in immunity, immunodeficiency, and cancer

JJ O'Shea, SM Holland, LM Staudt - New England Journal of …, 2013 - Mass Medical Soc
JAKs and STATs in Immunity, Immunodeficiency, and Cancer | New England Journal of Medicine
Skip to main content The New England Journal of Medicine homepage Advanced Search …

STATs in cancer inflammation and immunity: a leading role for STAT3

H Yu, D Pardoll, R Jove - Nature reviews cancer, 2009 - nature.com
Commensurate with their roles in regulating cytokine-dependent inflammation and immunity,
signal transducer and activator of transcription (STAT) proteins are central in determining …

JAK/STAT signaling in hematological malignancies

W Vainchenker, SN Constantinescu - Oncogene, 2013 - nature.com
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is
central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane …

Jaks and STATs: biological implications

WJ Leonard, JJ O'Shea - Annual review of immunology, 1998 - annualreviews.org
▪ Abstract Cytokines and interferons are molecules that play central roles in the regulation of
a wide array of cellular functions in the lympho-hematopoietic system. These factors …