T Hirano - International immunology, 2021 - academic.oup.com
IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …
WJ Leonard, JX Lin - Nature Reviews Drug Discovery, 2023 - nature.com
Cytokines are secreted or membrane-presented molecules that mediate broad cellular functions, including development, differentiation, growth and survival. Accordingly, the …
M Tolomeo, A Cascio - International journal of molecular sciences, 2021 - mdpi.com
Signal transducer and activator of transcription (STAT) 3 is one of the most complex regulators of transcription. Constitutive activation of STAT3 has been reported in many types …
TA Waldmann - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
Cytokines that control the immune response were shown to have efficacy in preclinical murine cancer models. Interferon (IFN)-α is approved for treatment of hairy cell leukemia …
Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays pivotal roles in the immune response. Discovered as a T cell growth factor, IL-2 additionally …
JJ O'Shea, SM Holland, LM Staudt - New England Journal of …, 2013 - Mass Medical Soc
JAKs and STATs in Immunity, Immunodeficiency, and Cancer | New England Journal of Medicine Skip to main content The New England Journal of Medicine homepage Advanced Search …
H Yu, D Pardoll, R Jove - Nature reviews cancer, 2009 - nature.com
Commensurate with their roles in regulating cytokine-dependent inflammation and immunity, signal transducer and activator of transcription (STAT) proteins are central in determining …
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane …
▪ Abstract Cytokines and interferons are molecules that play central roles in the regulation of a wide array of cellular functions in the lympho-hematopoietic system. These factors …