Tetrahydrofolate cofactors are essential for the synthesis of purines, certain amino acids,
and thymidine. Most bacteria and plants produce these folate cofactors by de novo …

Besides worthy development in cancer therapy, cancer is still one of the leading causes of
death, worldwide. The future burden of cancer will probably be even larger because people …

Ferroptosis is a regulated form of necrotic cell death implicated in carcinogenesis and
neurodegeneration that is driven by phospholipid peroxidation. Lipid-derived electrophiles …

Objectives To synthesize a variety of pyrimidine analogs, 3, 4, 5, 6 (a–d), 7 (a–d) and their
anticonvulsant and antioxidant activity was determined. Methods Using 5-bromo-2, 4 …

Thymidylate synthase (TS) is a well-validated target for cancer chemotherapy. TS was
established as the principal target of the widely used anticancer drug 5-fluorouracil (5FU) …

Sažetak The bifunctional pyrazolopyridine (2) and pyrano-pyrazole (3) derivatives were
prepared by the reaction of 2-(2, 4-dinitrophenyl)-5-methyl-2, 4-dihydro-3H-pyrazol-3-one …

Antifolates that inhibit the key enzymes thymidylate synthase (TS) and dihydrofolate
reductase (DHFR) have found clinical utility as antitumor and antiopportunistic agents …

The treatment of Human African trypanosomiasis remains a major unmet health need in sub-
Saharan Africa. Approaches involving new molecular targets are important; pteridine …

Opportunistic infections are known to cause morbidity and mortality in immunocompromised
individuals. In addition, serious infections due to several parasites are also known to affect …

Biochemically active Cu (II) and Zn (II) complexes [CuL (ClO 4) 2 (1) and ZnL (ClO 4) 2 (2)]
have been synthesized from N, N donor Schiff base ligand L derived from4, 6 …