Simple Summary Prostate cancer (PCa) is a widespread malignancy, representing the
second leading cause of cancer-related death in men. In the last years, liquid biopsy has …

Prostate cancer remains a life-threatening disease among men worldwide. The majority of
PCa-related mortality results from metastatic disease that is characterized by metastasis of …

Objectives. Various methods have been proposed to increase the specificity of prostate-
specific antigen (PSA), including age-specific PSA reference ranges, PSA density (PSAD) …

The introduction of total prostate specific antigen (total PSA) testing in blood has
revolutionized the detection and management of men with prostate cancer (PCa). The …

Sensitive detection of low-abundance proteins in complex biological samples has typically
been achieved by immunoassays that use antibodies specific to target proteins; however, de …

Recent studies on human kallikrein 2 (hK2) have revealed striking similarities and significant
differences with the closely related kallikrein PSA. Both PSA and hK2 are primarily localized …

Current tendencies in the treatment course of prostate cancer patients increase the need for
reliable biomarkers that help in decision-making in a challenging clinical setting. Within the …

Proteomics discovery leads to a list of potential protein biomarkers that have to be
subsequently verified and validated with a statistically viable number of patients. Although …

The measurement of prostate-specific antigen in serum is credited with dramatic advances
in the early detection of men with prostatic carcinoma. This report summarizes the history of …

PURPOSE: We reviewed the use of percent free prostate specific antigen (PSA) to enhance
specificity of PSA testing and aid in the discrimination of benign and malignant prostate …