Mutations in the gene BEST1 are causally associated with as many as five clinically distinct
retinal degenerative diseases, which are collectively referred to as the “bestrophinopathies” …

An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a
homopentameric cation channel that is important for virus pathogenicity. Here we report a …

Symmetry is a common feature among natural systems, including protein structures. A strong
propensity toward symmetric architectures has long been recognized for water-soluble …

Many organisms sense light using rhodopsins, photoreceptive proteins containing a retinal
chromophore. Here we report the discovery, structure and biophysical characterization of …

Quantitative fundus autofluorescence (qAF) is an approach that is built on a confocal
scanning laser platform and used to measure the intensity of the inherent autofluorescence …

Abstract Bestrophin-1 (Best1) is an anion channel genetically linked to vision-threatening
retinal degenerative channelopathies. Here, we identify interactions between Best1 and …

Bestrophinopathies, one of the most common forms of inherited macular degenerations, are
caused by mutations in the BEST1 gene expressed in the retinal pigment epithelium (RPE) …

Approximately one-third of the Earth's photosynthetic CO2 assimilation occurs in a pyrenoid,
an organelle containing the CO2-fixing enzyme Rubisco. How constituent proteins are …

Highly selective ion separation is crucial to engineering applications. In this work, inspired
by the working mechanism of biological protein ion channels, inclusion of ion-imprinted …

Abstract Bestrophin-1 (Best1) and bestrophin-2 (Best2) are two members of the bestrophin
family of calcium (Ca2+)-activated chloride (Cl−) channels with critical involvement in ocular …