Antioxidants: Classification, natural sources, activity/capacity measurements, and usefulness for the synthesis of nanoparticles

J Flieger, W Flieger, J Baj, R Maciejewski - Materials, 2021 - mdpi.com
Natural extracts are the source of many antioxidant substances. They have proven useful not
only as supplements preventing diseases caused by oxidative stress and food additives …

Biological and physiological role of reactive oxygen species–the good, the bad and the ugly

L Zuo, T Zhou, BK Pannell, AC Ziegler… - Acta …, 2015 - Wiley Online Library
Reactive oxygen species (ROS) are chemically reactive molecules that are naturally
produced within biological systems. Research has focused extensively on revealing the …

[HTML][HTML] Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1

P Luo, D Liu, Q Zhang, F Yang, YK Wong, F Xia… - … Pharmaceutica Sinica B, 2022 - Elsevier
Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid
peroxidation in an iron-and ROS-dependent manner. Celastrol, a natural bioactive …

Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases

S Cui, A Ghai, Y Deng, S Li, R Zhang, C Egbulefu… - Molecular cell, 2023 - cell.com
Ferroptosis, a regulated cell death pathway driven by accumulation of phospholipid
peroxides, has been challenging to identify in physiological conditions owing to the lack of a …

Paradoxical roles of antioxidant enzymes: basic mechanisms and health implications

XG Lei, JH Zhu, WH Cheng, Y Bao… - Physiological …, 2016 - journals.physiology.org
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …

Thioredoxins, glutaredoxins, and peroxiredoxins—molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling

EM Hanschmann, JR Godoy, C Berndt… - Antioxidants & redox …, 2013 - liebertpub.com
Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Studies on oxidants and antioxidants with a brief glance at their relevance to the immune system

BA Aslani, S Ghobadi - Life sciences, 2016 - Elsevier
Free radical generation occurs continuously within cells as a consequence of common
metabolic processes. However, in high concentrations, whether from endogenous or …

How mitochondria produce reactive oxygen species

MP Murphy - Biochemical journal, 2009 - portlandpress.com
The production of ROS (reactive oxygen species) by mammalian mitochondria is important
because it underlies oxidative damage in many pathologies and contributes to retrograde …

Celastrol attenuates angiotensin II–induced cardiac remodeling by targeting STAT3

S Ye, W Luo, ZA Khan, G Wu, L Xuan, P Shan… - Circulation …, 2020 - Am Heart Assoc
Rationale: Excessive Ang II (angiotensin II) levels lead to a profibrotic and hypertrophic
milieu that produces deleterious remodeling and dysfunction in hypertension-associated …

What is the concentration of hydrogen peroxide in blood and plasma?

HJ Forman, A Bernardo, KJA Davies - Archives of biochemistry and …, 2016 - Elsevier
The concentration of hydrogen peroxide (H 2 O 2) in blood and plasma is a measurement
that has often been made, but the absolute values remain unsettled due the great variability …