Cannabis sativa is the most widely used illicit drug in the world. Its main psychoactive
component is delta‐9‐tetrahydrocannabinol (THC), one of over 100 phytocannabinoid …

Preclinical and clinical studies implicate endocannabinoids (eCBs) in fear extinction, but the
underlying neural circuit basis of these actions is unclear. Here, we employed in vivo …

Targeting the endocannabinoid (eCB) signaling system for pain relief is an important
treatment option that is only now beginning to be mechanistically explored. In this review, we …

Endocannabinoids (eCB) and cannabinoid receptor 1 (CB1) play important roles in
mediating short-and long-term synaptic plasticity in many brain regions involved in learning …

Astrocytes are pivotal for synaptic transmission and may also play a role in the induction and
expression of synaptic plasticity, including endocannabinoid-mediated long-term depression …

Fetal alcohol exposure has deleterious consequences on the motor skills of patients affected
by Fetal Alcohol Spectrum Disorder (FASD) and in pre-clinical models of gestational ethanol …

Introduction: The endocannabinoids (eCBs), 2-arachidonoylglycerol (2-AG) and
arachidonoyl ethanolamine (AEA), are produced by separate enzymatic pathways, activate …

Major depressive disorder (MDD) is a life-impairing disorder, and early successful treatment
is important for a favorable prognosis. However, early response to antidepressants differs …

Background and Purpose Neurotransmission and neuroinflammation are controlled by local
increases in both extracellular ATP and the endocannabinoid 2‐arachidonoyl glycerol (2 …

Metabotropic glutamate receptor 5 (mGlu 5) is widely expressed throughout the central
nervous system and is involved in neuronal function, synaptic transmission, and a number of …