Lipoprotein lipase: from gene to obesity

H Wang, RH Eckel - American Journal of Physiology …, 2009 - journals.physiology.org
Lipoprotein lipase (LPL) is a multifunctional enzyme produced by many tissues, including
adipose tissue, cardiac and skeletal muscle, islets, and macrophages. LPL is the rate …

Lipoprotein lipase: structure, function, regulation, and role in disease

JR Mead, SA Irvine, DP Ramji - Journal of molecular medicine, 2002 - Springer
Lipoprotein lipase (LPL) catalyses the hydrolysis of the triacylglycerol component of
circulating chylomicrons and very low density lipoproteins, thereby providing non-esterified …

Lipoprotein lipase

M Merkel, RH Eckel, IJ Goldberg - Journal of lipid research, 2002 - ASBMB
Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects
are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and …

Interferon gamma: a master regulator of atherosclerosis

JE McLaren, DP Ramji - Cytokine & growth factor reviews, 2009 - Elsevier
Atherosclerosis is a chronic inflammatory disease that is characterized by the development
of fibrotic plaques in the arterial wall. The disease exhibits a complex aetiology and its …

Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism

K Preiss-Landl, R Zimmermann… - Current opinion in …, 2002 - journals.lww.com
Lipoprotein lipase: the regulation of tissue specific expres... : Current Opinion in Lipidology
Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy …

Interferon-γ interferes with transforming growth factor-β signaling through direct interaction of YB-1 with Smad3

K Higashi, Y Inagaki, K Fujimori, A Nakao… - Journal of Biological …, 2003 - ASBMB
Transforming growth factor-β (TGF-β) and interferon-γ (IFN-γ) exert antagonistic effects on
collagen synthesis in human dermal fibroblasts. We have recently shown that Y box-binding …

Interferon-γ and atherosclerosis: pro-or anti-atherogenic?

EJ Harvey, DP Ramji - Cardiovascular research, 2005 - academic.oup.com
Atherosclerosis is considered to be a form of chronic inflammation governed by a complex
network of inter-and intra-cellular signaling pathways. The pleiotropic cytokine interferon-γ …

Opposing roles of IL-10 in acute bacterial infection

HF Peñaloza, BM Schultz, PA Nieto, GA Salazar… - Cytokine & growth factor …, 2016 - Elsevier
Abstract Interleukin-10 (IL-10) is recognized as an anti-inflammatory cytokine that
downmodulates inflammatory immune responses at multiple levels. In innate cells …

Role of Sp1 in atherosclerosis

JF Jiang, ZY Zhou, YZ Liu, L Wu, BB Nie… - Molecular Biology …, 2022 - Springer
Specificity protein (Sp) is a famous family of transcription factors including Sp1, Sp2 and
Sp3. Sp1 is the first one of Sp family proteins to be characterized and cloned in mammalian …

The pivotal role of lipoprotein lipase in atherosclerosis

JR Mead, DP Ramji - Cardiovascular research, 2002 - academic.oup.com
1. Introduction acids and 2-monoacylglycerols for tissue utilization [3, 4]. Due to the large
size of its substrates, the physiological site Atherosclerosis, the underlying cause of heart …