Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older
people, which severely impairs patients' quality of life. In the recent years, the number of …

Since the brain was found to be somehow flexible, plastic, researchers worldwide have
been trying to comprehend its fundamentals to better understand the brain itself, make …

Hippocampal synaptic plasticity is widely considered the cellular basis of learning and
spatial memory processes. This article highlights the central role of Ca 2+ release from the …

The plasticity mechanisms in the nervous system that are important for learning and memory
are greatly impacted during aging. Notably, hippocampal‐dependent long‐term plasticity …

The expression of several hippocampal genes implicated in learning and memory
processes requires that Ca2+ signals generated in dendritic spines, dendrites, or the soma …

A predominant view of perirhinal cortex (PRC) and postrhinal/parahippocampal cortex
(POR/PHC) function contends that these structures are tuned to represent objects and …

Aging is a progressive process leading to functional decline in many domains. Recent
studies have shown that physical exercise (PE) has a positive influence on the progression …

Dietary restriction of the essential amino acid, methionine, has been shown to induce unique
metabolic protection. The peripheral benefits of methionine restriction (MR) are well …

Introduction Centella asiatica is a plant used for centuries to enhance memory. We have
previously shown that a water extract of Centella asiatica (CAW) attenuates age‐related …

We have previously reported that primary hippocampal neurons exposed to synaptotoxic
amyloid beta oligomers (AβOs), which are likely causative agents of Alzheimer's disease …