Chemical modification of proteins–challenges and trends at the start of the 2020s

NH Fischer, MT Oliveira, F Diness - Biomaterials Science, 2023 - pubs.rsc.org
Ribosomally expressed proteins perform multiple, versatile, and specialized tasks
throughout Nature. In modern times, chemically modified proteins, including improved …

Romp-based glycopolymers with high affinity for mannose-binding lectins

C Gonnot, M Scalabrini, B Roubinet, C Ziane… - …, 2023 - ACS Publications
Well-defined, highly reactive poly (norbornenyl azlactone) s of controlled length (number-
average degree of polymerization DP n¯= 10 to 1,000) were made by ring-opening …

Poly (2-isopropenyl-2-oxazoline) as a reactive polymer for materials development

B Kopka, B Kost, M Basko - Polymer Chemistry, 2022 - pubs.rsc.org
Poly (2-isopropenyl-2-oxazoline) has attracted growing interest as a reactive polymer that
can be used as a starting material for the construction of more complex structures containing …

Bioconjugates–From a specialized past to a diverse future

KM Burridge, RC Page, D Konkolewicz - Polymer, 2020 - Elsevier
Proteins are the quintessential well-designed macromolecules–functional, specific,
biodegradable, and biocompatible. They have been modified with other macromolecules …

A quantification of target protein biomarkers in complex media by faradaic shotgun tagging

M Sharafeldin, F Fleschhut, T James… - Analytical …, 2022 - ACS Publications
The progressive emergence of protein biomarkers promises a revolution in the healthcare
industry and a shift of focus from disease management to much earlier intervention. Here …

Poly (2-isopropenyl-2-oxazoline)–a structural analogue to poly (vinyl azlactone) with Orthogonal Reactivity

MN Leiske, AM Mahmoud, NM Warne, JACM Goos… - Polymer …, 2020 - pubs.rsc.org
In this study, we report a straightforward method to orthogonally functionalise (co) polymers
of two independently addressable reactive monomers–the structural analogues 2 …

Activity-based proteomic profiling: the application of photoaffinity probes in the target identification of bioactive molecules

J Wang, Q Chen, Y Shan, X Pan, J Zhang - TrAC Trends in Analytical …, 2019 - Elsevier
Identifying cellular targets for bioactive molecules is a major challenge and a key issue in
drug discovery. Small molecule probes play an essential role in identifying targets of …

[HTML][HTML] Well-defined amine-reactive polymethacrylates through organocatalyzed controlled radical polymerization

V Montembault, S Pascual, L Fontaine, D Gigmes… - Polymer …, 2022 - pubs.rsc.org
A novel alkyl iodide bearing an azlactone group was synthesized and used as a reversible
complex-mediated polymerization (RCMP) initiator for the organocatalyzed RCMP of methyl …

Poly (norbornenyl azlactone) as a versatile platform for sequential double click postpolymerization modification

F François, C Nicolas, G Forcher, L Fontaine… - European Polymer …, 2020 - Elsevier
Ring-opening metathesis polymerization (ROMP) of a heterofunctional azlactone-based
monomer, namely norbornenyl azlactone (NBAzl), is reported for the first time using third …

One stone two birds: from one azlactone-functionalized monomer to a heterofunctional diblock copolymer

F François, G Gody, J Wilson, L Fontaine… - Polymer …, 2024 - pubs.rsc.org
Demonstrated is the successful implementation of a novel route for the preparation of
heterofunctional diblock copolymers derived from 2-vinyl-4, 4-dimethyl azlactone (VDM) by …