In sexually reproducing organisms, life begins with the fusion of transcriptionally silent
gametes, the oocyte and sperm. Although initiation of transcription in the embryo, known as …

Summary H3K9me3, as a hallmark of heterochromatin, is important for cell-fate specification.
However, it remains unknown how H3K9me3 is reprogrammed during human early embryo …

The activation of the zygotic genome constitutes an essential process during early
embryogenesis that determines the overall progression of embryonic development. Zygotic …

Although parental genomes undergo extensive epigenetic reprogramming to be equalized
after fertilization, whether they play different roles in human zygotic genome activation (ZGA) …

Embryonic genome activation (EGA) is critical for embryonic development. However, our
understanding of the regulatory mechanisms of human EGA is still incomplete. Human …

How histone modifications regulate changes in gene expression during preimplantation
development in any species remains poorly understood. Using CUT&Tag to overcome …

Embryonic genome activation (EGA) occurs during preimplantation development and is
characterized by the initiation of de novo transcription from the embryonic genome. Despite …

Zygotic genome activation (ZGA), the first transcription event following fertilization, kickstarts
the embryonic program that takes over the control of early development from the maternal …

The totipotent embryo initiates transcription during zygotic or embryonic genome activation
(EGA, ZGA). ZGA occurs at the 8-cell stage in humans and its failure leads to developmental …

The paired-like homeobox transcription factor LEUTX is expressed in human
preimplantation embryos between the 4-and 8-cell stages, and then silenced in somatic …