The human immunodeficiency virus (HIV) genome encodes a total of three structural
proteins, two envelope proteins, three enzymes, and six accessory proteins. Studies over the …

HIV assembly and replication proceed through the formation of morphologically distinct
immature and mature viral capsids that are organized by the Gag polyprotein (immature) …

During the late phase of HIV type 1 (HIV-1) replication, newly synthesized retroviral Gag
proteins are targeted to the plasma membrane of most hematopoietic cell types, where they …

Exosomes are secreted organelles that have the same topology as the cell and bud outward
(outward is defined as away from the cytoplasm) from endosome membranes or endosome …

The three-dimensional structure of the amino-terminal core domain (residues 1 through 151)
of the human immunodeficiency virus-type 1 (HIV-1) capsid protein has been solved by …

Domains have been identified in the Gag proteins of a number of retroviruses, and in the
matrix proteins of the rhabdoviruses and filoviruses, that play a critical role in the pinching off …

The myristoylated matrix protein (myr-MA) of HIV functions as a regulator of intracellular
localization, targeting the Gag precursor polyprotein to lipid rafts in the plasma membrane …

We recently demonstrated that a single amino acid substitution in matrix residue 12 (12LE)
or 30 (30LE) blocks the incorporation of human immunodeficiency virus type 1 (HIV-1) …

Incorporation of envelope glycoproteins into a budding retrovirus is an essential step in the
formation of an infectious virus particle. By using site-directed mutagenesis, we identified …

The karyophilic properties of the viral matrix (MA) protein govern HIV nuclear import in
nondividing cells such as macrophages. A critical regulator of this process is the C-terminal …