Single cell transcriptome analyses of the developing zebrafish eye—perspectives and applications

O Vöcking, JK Famulski - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Within a relatively short period of time, single cell transcriptome analyses (SCT) have
become increasingly ubiquitous with transcriptomic research, uncovering plentiful details …

Fishing Innate Immune System Properties through the Transcriptomic Single-Cell Data of Teleostei

AV Bobrovskikh, US Zubairova, AV Doroshkov - Biology, 2023 - mdpi.com
Simple Summary The study of the innate immune system's (IIS) properties is one of the key
tasks of modern immunology, since it could help enhance the quality of therapy and drug …

Restoration of cone-circuit functionality in the regenerating adult zebrafish retina

E Abraham, H Hartmann, T Yoshimatsu, T Baden… - Developmental Cell, 2024 - cell.com
Unlike humans, teleosts like zebrafish exhibit robust retinal regeneration after injury from
endogenous stem cells. However, it is unclear if regenerating cone photoreceptors regain …

Inflammation is a critical factor for successful regeneration of the adult zebrafish retina in response to diffuse light lesion

O Bludau, A Weber, V Bosak, V Kuscha… - Frontiers in Cell and …, 2024 - frontiersin.org
Inflammation can lead to persistent and irreversible loss of retinal neurons and
photoreceptors in mammalian vertebrates. In contrast, in the adult zebrafish brain, acute …

A large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration

K Emmerich, J Hageter, T Hoang, P Lyu… - …, 2024 - journals.biologists.com
Many genes are known to regulate retinal regeneration after widespread tissue damage.
Conversely, genes controlling regeneration after limited cell loss, as per degenerative …

Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina

P Lyu, M Iribarne, D Serjanov, Y Zhai, T Hoang… - Nature …, 2023 - nature.com
Following acute retinal damage, zebrafish possess the ability to regenerate all neuronal
subtypes through Müller glia (MG) reprogramming and asymmetric cell division that …

[HTML][HTML] Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina

S Blackshaw, P Lyu, Y Zhai, J Qian, M Iribarne… - Research …, 2023 - ncbi.nlm.nih.gov
Following acute retinal damage, zebrafish possess the ability to regenerate all neuronal
subtypes. This regeneration requires Müller glia (MG) to reprogram and divide …

Successful regeneration of the adult zebrafish retina is dependent on inflammatory signaling

O Bludau, A Weber, V Bosak, V Kuscha, K Dietrich… - bioRxiv, 2023 - biorxiv.org
Inflammation can lead to persistent and irreversible loss of retinal neurons and
photoreceptors in mammalian vertebrates. In contrast, in the adult zebrafish brain, acute …

Human Amniotic Epithelial Cells Promote Chx10-/Pax6+ Muller Glia Subpopulation Reprogramming into Photoreceptor-like Cells

H Gao, Z Yin, X Huang, Y Zeng, T Zou, C Zhe, X Cheng… - bioRxiv, 2024 - biorxiv.org
Reprogramming Muller glia to regenerate neurons is a promising strategy for treating retinal
degeneration, but whether Muller glia contain subpopulations with different regenerative …

DIVERGENT MECHANISMS UNDERLYING CELLULAR REGENERATION IN THE ZEBRAFISH RETINA

KB Emmerich - 2023 - jscholarship.library.jhu.edu
Problem: Retinal neurodegenerative diseases lead to loss of vision in humans, with no
cures in place to replace vision once it is lost. These diseases involve the loss of individual …