Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

Actin-depolymerization factor (ADF)/cofilin, a family of actin-binding proteins, are critical for
the regulation of actin reorganization in response to various signals. Accumulating evidence …

The phospholipid and free fatty acid (FFA) composition of neuronal membranes plays a
crucial role in learning and memory, but the mechanisms through which neuronal activity …

Abstract Apolipoprotein E ε4 (APOE4) is the primary genetic risk factor for the late-onset form
of Alzheimer's disease (AD). Although the reason for this association is not completely …

Mammalian phospholipase D (PLD) generates phosphatidic acid, a dynamic lipid secondary
messenger involved with a broad spectrum of cellular functions including but not limited to …

Phosphatidylinositol is the parent lipid for the synthesis of seven phosphorylated inositol
lipids and each of them play specific roles in numerous processes including receptor …

Enzymes that produce second messengers are highly regulated. Revealing the mechanisms
underlying such regulation is critical to understanding both how cells achieve specific …

This study investigated the role of phospholipase D (PLD) in retinal ischemia–reperfusion
(I/R) injury using an oxygen‐glucose deprivation/reperfusion (OGD/R) model commonly …

Takeda G protein‐coupled receptor 5 (TGR5) is the first known G protein‐coupled receptor
specific for bile acids and is recognized as a new and critical target for type 2 diabetes and …

Specific forms of fatty acids are well known to have beneficial health effects, but their precise
mechanism of action remains elusive. Phosphatidic acid (PA) produced by phospholipase …