Disease and accompanying inflammation are uncommon outcomes of viral infection in
humans. Clinical inflammation occurs if steady-state cell-intrinsic and leukocytic immunity to …

African trypanosomes are bloodstream protozoan parasites that infect mammals including
humans, where they cause sleeping sickness. Long-lasting infection is required to favor …

The abuse of antibiotics has led to the emergence of multidrug-resistant microbial
pathogens, presenting a pressing challenge in global healthcare. Membrane-disrupting …

Understanding protective immunity to COVID-19 facilitates preparedness for future
pandemics and combats new SARS-CoV-2 variants emerging in the human population …

Peroxisomes are organelles involved in many metabolic processes including lipid
metabolism, reactive oxygen species (ROS) turnover, and antimicrobial immune responses …

The molecular basis of interindividual clinical variability upon infection with Staphylococcus
aureus is unclear. We describe patients with haploinsufficiency for the linear deubiquitinase …

In 1955, René Dubos famously expressed his “second thoughts on the germ theory”,
attributing infectious diseases to various “changing circumstances” that weaken the host by …

In the competition between the pathogen infection and the host defense, infectious
microorganisms may enter the host cells by evading host defense mechanisms and use the …

Biomarker discovery is essential for the understanding, diagnosis, targeted therapy and
prognosis assessment of malignant diseases. However, it remains a huge challenge due to …

Immunity to infection has been extensively studied in humans and mice bearing naturally
occurring or experimentally introduced germline mutations. Mouse studies are sometimes …