Sphingolipid metabolism in metazoan cells consists of a complex interconnected web of
numerous enzymes, metabolites and modes of regulation. At the centre of sphingolipid …

Intensive research over the past 2 decades has implicated ceramide in the regulation of
several cell responses. However, emerging evidence points to dramatic complexities in …

In mammals, ceramide, a key intermediate in sphingolipid metabolism and an important
signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of …

Ceramides are a class of sphingolipids that are abundant in cell membranes. They are
important structural components of the membrane but can also act as second messengers in …

Apoptosis and autophagy are two evolutionarily conserved processes that maintain
homeostasis during stress. Although the two pathways utilize fundamentally distinct …

In an approach aimed at defining interacting partners of ceramide synthases (CerSs), we
found that fatty acyl-CoA synthase ACSL5 interacts with all CerSs. We demonstrate that …

2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

Different studies corroborate a role for ceramide synthases and their downstream products,
ceramides, in modulation of apoptosis and autophagy in the context of cancer. These …

Abstract S phingosine-1-phosphate (S1P) is a bioactive lipid mediator with crucial roles in a
wide variety of cellular functions across a broad range of organisms. Though a simple …

Sphingolipids have emerged as bioeffector molecules, controlling various aspects of cell
growth and proliferation in cancer, which is becoming the deadliest disease in the world …