[HTML][HTML] Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

SV Bhujbal, B Mitra, U Jain, Y Gong, A Agrawal… - … Pharmaceutica Sinica B, 2021 - Elsevier
Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …

Polymeric amorphous solid dispersions: a review of amorphization, crystallization, stabilization, solid-state characterization, and aqueous solubilization of …

S Baghel, H Cathcart, NJ O'Reilly - Journal of pharmaceutical sciences, 2016 - Elsevier
Poor water solubility of many drugs has emerged as one of the major challenges in the
pharmaceutical world. Polymer-based amorphous solid dispersions have been considered …

Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers

A Sosnik, KP Seremeta - Advances in colloid and interface science, 2015 - Elsevier
Spray-drying is a rapid, continuous, cost-effective, reproducible and scalable process for the
production of dry powders from a fluid material by atomization through an atomizer into a hot …

Spray drying formulation of amorphous solid dispersions

A Singh, G Van den Mooter - Advanced drug delivery reviews, 2016 - Elsevier
Spray drying is a well-established manufacturing technique which can be used to formulate
amorphous solid dispersions (ASDs) which is an effective strategy to deliver poorly water …

Amorphous solid dispersions: Rational selection of a manufacturing process

T Vasconcelos, S Marques, J das Neves… - Advanced drug delivery …, 2016 - Elsevier
Amorphous products and particularly amorphous solid dispersions are currently one of the
most exciting areas in the pharmaceutical field. This approach presents huge potential and …

Chitosan coated magnetic nanoparticles as carriers of anticancer drug Telmisartan: pH-responsive controlled drug release and cytotoxicity studies

RP Dhavale, RP Dhavale, SC Sahoo, P Kollu… - Journal of Physics and …, 2021 - Elsevier
Chitosan, a natural, hydrophilic and biodegradable polymer was grafted on Fe 3 O 4
magnetic nanoparticles (MNPs) and used as a carrier of poorly water-soluble anticancer …

The synthesis of bacterial cellulose-chitosan zwitterionic hydrogels with pH responsiveness for drug release mechanism of the naproxen

K Jiang, X Zhou, T He - International Journal of Biological Macromolecules, 2022 - Elsevier
The human digestive and absorption system has a specific pH environment, which makes it
difficult to for accurate drug-release. Zwitterionic hydrogel, as a kind of drug carrier, is a …

[HTML][HTML] Development, recent advances, and updates in binary, ternary co-amorphous systems, and ternary solid dispersions

A Saberi, M Kouhjani, D Yari, A Jahani… - Journal of Drug Delivery …, 2023 - Elsevier
Binary co-amorphous systems (CAMS) are a type of solid dispersion containing an active
pharmaceutical ingredient (API) and small molecule excipients. The properties of these …

Hypromellose acetate succinate based amorphous solid dispersions via hot melt extrusion: Effect of drug physicochemical properties

S Sarabu, VR Kallakunta, S Bandari, A Batra, V Bi… - Carbohydrate …, 2020 - Elsevier
In this study, the impact of drug and hydroxypropyl methylcellulose acetate succinate
(HPMCAS) grades physicochemical properties on extrusion process, dissolution and …

Hot-melt extruded amorphous solid dispersion for solubility, stability, and bioavailability enhancement of telmisartan

BR Giri, J Kwon, AQ Vo, AM Bhagurkar, S Bandari… - Pharmaceuticals, 2021 - mdpi.com
Telmisartan (TEL, an antihypertensive drug) belongs to Class II of the Biopharmaceutical
Classification System (BCS) because of its poor aqueous solubility. In this study, we …