Natural biomaterials for corneal tissue engineering, repair, and regeneration

RN Palchesko, SD Carrasquilla… - Advanced healthcare …, 2018 - Wiley Online Library
Corneal blindness is a major cause of vision loss, estimated to affect over 10 million people
worldwide. Once impaired through clouding or shape change, the best treatment option for …

[HTML][HTML] Review of ex-vivo characterisation of corneal biomechanics

JJ Wang, XY Liu, FJ Bao, BT Lopes, LZ Wang… - Medicine in Novel …, 2021 - Elsevier
The evaluation of the corneal biomechanical behaviour has important clinical applications.
To name a few, the accuracy of the intraocular pressure measurement, the study of corneal …

A decellularized human corneal scaffold for anterior corneal surface reconstruction

N Polisetti, A Schmid, U Schlötzer-Schrehardt… - Scientific reports, 2021 - nature.com
Allogenic transplants of the cornea are prone to rejection, especially in repetitive
transplantation and in scarred or highly vascularized recipient sites. Patients with these …

Use of Nanoindentation in Determination of Regional Biomechanical Properties of Rabbit Cornea After UVA Cross-Linking

X Zheng, Y Xin, C Wang, Y Fan, P Yang… - … & visual science, 2023 - iovs.arvojournals.org
Purpose: To evaluate the regional effects of different corneal cross-linking (CXL) protocols
on corneal biomechanical properties. Methods: The study involved both eyes of 50 rabbits …

The impact of substrate stiffness on morphological, transcriptional and functional aspects in RPE

L Wolfram, C Gimpel, M Schwämmle, SJ Clark… - Scientific Reports, 2024 - nature.com
Alterations in the structure and composition of Bruch's membrane (BrM) and loss of retinal
pigment epithelial (RPE) cells are associated with various ocular diseases, notably age …

Effective elastic modulus of an intact cornea related to indentation behavior: A comparison between the Hertz model and Johnson-Kendall-Roberts model

QM Ren, J Chen, XN Li, Y Lv, XL Niu, WY Chen… - Experimental Eye …, 2021 - Elsevier
In this study, a macro-indentation test on the submillimeter scale was performed to analyze
the indentation behavior of an intact cornea under physiological pressures. The Hertz and …

3D printing of stiff, tough, and ROS-scavenging nanocomposite hydrogel scaffold for in situ corneal repair

T Li, X Zhang, L Ma, X Qi, H Wang, Q Zhou, X Sun… - Acta Biomaterialia, 2024 - Elsevier
Despite significant advancements in hydrogels in recent years, their application in corneal
repair remains limited by several challenges, including unfitted curvatures, inferior …

Two-photon crosslinking in collagen hydrogel towards corneal tissue engineering

J An, Z Cheng, L Chang, H Liu, W Qian, N Zhang… - Optics & Laser …, 2024 - Elsevier
Corneal disease seriously threatens the quality of human vision and even causes blindness,
but the shortage of corneal donors is insufficient to meet the demand for corneal …

[HTML][HTML] Full-field strain mapping for characterization of structure-related variation in corneal biomechanical properties using digital image correlation (DIC) technology

X Qiao, D Chen, H Huo, M Tang, Z Tang, Y Dong… - Medicine in Novel …, 2021 - Elsevier
Abstract Characterization of structure-related variation in corneal biomechanical properties
is important for the design of corneal implants with a controllable degradation. In the current …

Characterization of the Immediate and Delayed Biomechanical Response to UV-A Crosslinking of Human Corneas

AKM Ross, G Schlunck, D Böhringer, P Maier… - Cornea, 2023 - journals.lww.com
Purpose: Keratoconus leads to visual deterioration due to irregular astigmatism and corneal
thinning. Riboflavin-based corneal UV-A crosslinking (CXL) induces novel intramolecular …