In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

A central mechanism regulating translation initiation in response to environmental stress
involves phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) …

Translation regulation largely occurs during initiation, which features ribosome assembly
onto mRNAs and selection of the translation start site. Short, upstream ORFs (uORFs) …

The integrated stress response (ISR) is an evolutionarily conserved intra-cellular signaling
network which is activated in response to intrinsic and extrinsic stresses. Various stresses …

Regeneration of adult tissues depends on somatic stem cells that remain quiescent yet are
primed to enter a differentiation program. The molecular pathways that prevent activation of …

Disturbances in protein folding and membrane compositions in the endoplasmic reticulum
(ER) elicit the unfolded protein response (UPR). Each of three UPR sensory proteins …

Taking advantage of natural variation promotes our understanding of phenotypic diversity
and trait evolution, ultimately accelerating plant breeding, in which the identification of …

The integrated stress response (ISR) is a homeostatic mechanism induced by endoplasmic
reticulum (ER) stress. In acute/transient ER stress, decreased global protein synthesis and …

As it is well known, messenger RNA has many regulatory regions along its sequence length.
One of them is the 5′ untranslated region (5'UTR), which itself contains many regulatory …

The integrated stress response (ISR) is an essential stress-support pathway increasingly
recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in …