New frontiers in immune checkpoint B7-H3 (CD276) research and drug development

AA Getu, A Tigabu, M Zhou, J Lu, Ø Fodstad, M Tan - Molecular Cancer, 2023 - Springer
Abstract B7-H3 (CD276), a member of the B7 family of proteins, is a key player in cancer
progression. This immune checkpoint molecule is selectively expressed in both tumor cells …

Inside and out: the activities of senescence in cancer

PA Pérez-Mancera, ARJ Young, M Narita - Nature Reviews Cancer, 2014 - nature.com
The core aspect of the senescent phenotype is a stable state of cell cycle arrest. However,
this is a disguise that conceals a highly active metabolic cell state with diverse functionality …

[HTML][HTML] Distinct functions of senescence-associated immune responses in liver tumor surveillance and tumor progression

T Eggert, K Wolter, J Ji, C Ma, T Yevsa, S Klotz… - Cancer cell, 2016 - cell.com
Oncogene-induced senescence causes hepatocytes to secrete cytokines, which induce their
immune-mediated clearance to prevent tumor initiation, a process termed" senescence …

A photocaged, water-oxidizing, and nucleolus-targeted Pt (IV) complex with a distinct anticancer mechanism

Z Deng, N Wang, Y Liu, Z Xu, Z Wang… - Journal of the …, 2020 - ACS Publications
Targeted anticancer prodrugs that can be controllably activated are highly desired for
personalized precision medicine in cancer therapy. Such prodrugs with unique action …

Fibronectin in cancer: friend or foe

TC Lin, CH Yang, LH Cheng, WT Chang, YR Lin… - Cells, 2019 - mdpi.com
The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly
controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic …

Wnt5a signaling in cancer

MS Asem, S Buechler, RB Wates, DL Miller, MS Stack - Cancers, 2016 - mdpi.com
Wnt5a is involved in activating several non-canonical WNT signaling pathways, through
binding to different members of the Frizzled-and Ror-family receptors. Wnt5a signaling is …

Polyphenols as modulator of oxidative stress in cancer disease: new therapeutic strategies

AM Mileo, S Miccadei - Oxidative medicine and cellular …, 2016 - Wiley Online Library
Cancer onset and progression have been linked to oxidative stress by increasing DNA
mutations or inducing DNA damage, genome instability, and cell proliferation and therefore …

Inhibition of Bcl-2/xl with ABT-263 selectively kills senescent type II pneumocytes and reverses persistent pulmonary fibrosis induced by ionizing radiation in mice

J Pan, D Li, Y Xu, J Zhang, Y Wang, M Chen… - International Journal of …, 2017 - Elsevier
Purpose Ionizing radiation (IR)–induced pulmonary fibrosis (PF) is an irreversible and
severe late effect of thoracic radiation therapy. The goal of this study was to determine …

Targeting of cancer cell death mechanisms by resveratrol: a review

X Fu, M Li, C Tang, Z Huang, M Najafi - Apoptosis, 2021 - Springer
Cancer cell death is the utmost aim in cancer therapy. Anti-cancer agents can induce
apoptosis, mitotic catastrophe, senescence, or autophagy through the production of free …

The hypoxic microenvironment: A determinant of cancer stem cell evolution

A Carnero, M Lleonart - Inside the Cell, 2016 - Wiley Online Library
Tumors are often viewed as unique entities with specific behaviors. However, tumors are a
mixture of differentially evolved subpopulations of cells in constant Darwinian evolution …