PA Pérez-Mancera, ARJ Young, M Narita - Nature Reviews Cancer, 2014 - nature.com
The core aspect of the senescent phenotype is a stable state of cell cycle arrest. However, this is a disguise that conceals a highly active metabolic cell state with diverse functionality …
T Eggert, K Wolter, J Ji, C Ma, T Yevsa, S Klotz… - Cancer cell, 2016 - cell.com
Oncogene-induced senescence causes hepatocytes to secrete cytokines, which induce their immune-mediated clearance to prevent tumor initiation, a process termed" senescence …
Z Deng, N Wang, Y Liu, Z Xu, Z Wang… - Journal of the …, 2020 - ACS Publications
Targeted anticancer prodrugs that can be controllably activated are highly desired for personalized precision medicine in cancer therapy. Such prodrugs with unique action …
The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic …
MS Asem, S Buechler, RB Wates, DL Miller, MS Stack - Cancers, 2016 - mdpi.com
Wnt5a is involved in activating several non-canonical WNT signaling pathways, through binding to different members of the Frizzled-and Ror-family receptors. Wnt5a signaling is …
AM Mileo, S Miccadei - Oxidative medicine and cellular …, 2016 - Wiley Online Library
Cancer onset and progression have been linked to oxidative stress by increasing DNA mutations or inducing DNA damage, genome instability, and cell proliferation and therefore …
J Pan, D Li, Y Xu, J Zhang, Y Wang, M Chen… - International Journal of …, 2017 - Elsevier
Purpose Ionizing radiation (IR)–induced pulmonary fibrosis (PF) is an irreversible and severe late effect of thoracic radiation therapy. The goal of this study was to determine …
X Fu, M Li, C Tang, Z Huang, M Najafi - Apoptosis, 2021 - Springer
Cancer cell death is the utmost aim in cancer therapy. Anti-cancer agents can induce apoptosis, mitotic catastrophe, senescence, or autophagy through the production of free …
A Carnero, M Lleonart - Inside the Cell, 2016 - Wiley Online Library
Tumors are often viewed as unique entities with specific behaviors. However, tumors are a mixture of differentially evolved subpopulations of cells in constant Darwinian evolution …