Recent advances in Brucella abortus vaccines
EMS Dorneles, N Sriranganathan, AP Lage - Veterinary research, 2015 - Springer
Brucella abortus vaccines play a central role in bovine brucellosis control/eradication
programs and have been successfully used worldwide for decades. Strain 19 and RB51 are …
programs and have been successfully used worldwide for decades. Strain 19 and RB51 are …
Towards a Brucella vaccine for humans
SD Perkins, SJ Smither, HS Atkins - FEMS microbiology reviews, 2010 - academic.oup.com
There is currently no licensed vaccine for brucellosis in humans. Available animal vaccines
may cause disease and are considered unsuitable for use in humans. However, the …
may cause disease and are considered unsuitable for use in humans. However, the …
Development of a multi-epitope peptide vaccine inducing robust T cell responses against brucellosis using immunoinformatics based approaches
Current investigations have demonstrated that a multi-epitope peptide vaccine targeting
multiple antigens could be considered as an ideal approach for prevention and treatment of …
multiple antigens could be considered as an ideal approach for prevention and treatment of …
The advances in brucellosis vaccines
H Hou, X Liu, Q Peng - Vaccine, 2019 - Elsevier
Brucellosis is a worldwide zoonosis affecting animal and human health. Till now, there is no
effective vaccine licensed for brucellosis in humans. Although M5, H38 and 45/20 vaccines …
effective vaccine licensed for brucellosis in humans. Although M5, H38 and 45/20 vaccines …
Immunization with Recombinant Brucella Species Outer Membrane Protein Omp16 or Omp19 in Adjuvant Induces Specific CD4+ and CD8+ T Cells as Well as Systemic and …
KA Pasquevich, SM Estein, CG Samartino… - Infection and …, 2009 - Am Soc Microbiol
Available vaccines against Brucella spp. are live attenuated Brucella strains. In order to
engineer a better vaccine to be used in animals and humans, our laboratory aims to develop …
engineer a better vaccine to be used in animals and humans, our laboratory aims to develop …
Vaccination with the Recombinant Brucella Outer Membrane Protein 31 or a Derived 27-Amino-Acid Synthetic Peptide Elicits a CD4+ T Helper 1 Response That Protects …
J Cassataro, SM Estein, KA Pasquevich… - Infection and …, 2005 - Am Soc Microbiol
The immunogenicity and protective efficacy of the recombinant 31-kDa outer membrane
protein from Brucella melitensis (rOmp31), administered with incomplete Freund's adjuvant …
protein from Brucella melitensis (rOmp31), administered with incomplete Freund's adjuvant …
An Oral Vaccine Based on U-Omp19 Induces Protection against B. abortus Mucosal Challenge by Inducing an Adaptive IL-17 Immune Response in Mice
KA Pasquevich, AE Ibanez, LM Coria… - PloS one, 2011 - journals.plos.org
As Brucella infections occur mainly through mucosal surfaces, the development of mucosal
administered vaccines could be radical for the control of brucellosis. In this work we …
administered vaccines could be radical for the control of brucellosis. In this work we …
Vaccination with Brucella recombinant DnaK and SurA proteins induces protection against Brucella abortus infection in BALB/c mice
MV Delpino, SM Estein, CA Fossati, PC Baldi… - Vaccine, 2007 - Elsevier
The immunogenicity and protective efficacy of recombinant SurA (rSurA) and rDnaK from
Brucella spp. were evaluated in BALB/c mice. Immunization with rSurA in adjuvant induced …
Brucella spp. were evaluated in BALB/c mice. Immunization with rSurA in adjuvant induced …
Protective Immunity Elicited by a Divalent DNA Vaccine Encoding Both the L7/L12 and Omp16 Genes of Brucella abortus in BALB/c Mice
D Luo, B Ni, P Li, W Shi, S Zhang, Y Han… - Infection and …, 2006 - Am Soc Microbiol
This study was designed to evaluate the immunogenicity and the protective efficacy of a
divalent fusion DNA vaccine encoding both the Brucella abortus L7/L12 protein (ribosomal …
divalent fusion DNA vaccine encoding both the Brucella abortus L7/L12 protein (ribosomal …
The protein moiety of Brucella abortus outer membrane protein 16 is a new bacterial pathogen-associated molecular pattern that activates dendritic cells in vivo …
KA Pasquevich, C Garcia Samartino… - The Journal of …, 2010 - journals.aai.org
Knowing the inherent stimulatory properties of the lipid moiety of bacterial lipoproteins, we
first hypothesized that Brucella abortus outer membrane protein (Omp) 16 lipoprotein would …
first hypothesized that Brucella abortus outer membrane protein (Omp) 16 lipoprotein would …