The molecular mechanisms of cellular insulin action have been the focus of much
investigation since the discovery of the hormone 100 years ago. Insulin action is impaired in …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …

Obesity and hyperlipidemia are the most prevalent independent risk factors of chronic
kidney disease (CKD), suggesting that lipid accumulation in the renal parenchyma is …

Brown adipose tissue (BAT) and beige adipose tissue combust fuels for heat production in
adult humans, and so constitute an appealing target for the treatment of metabolic disorders …

Insulin is a major endocrine hormone also involved in the regulation of energy and lipid
metabolism via the activation of an intracellular signaling cascade involving the insulin …

Long-chain fatty acids and lipids serve a wide variety of functions in mammalian
homeostasis, particularly in the formation and dynamic properties of biological membranes …

Background Obesity is associated with increased recurrence and reduced survival of breast
cancer. Adipocytes constitute a significant component of breast tissue, yet their role in …

The uptake and metabolism of long chain fatty acids (LCFA) are critical to many
physiological and cellular processes. Aberrant accumulation or depletion of LCFA underlie …

Brown adipose tissue (BAT) is a therapeutic target for metabolic diseases; thus,
understanding its metabolic circuitry is clinically important. Many studies of BAT compare …