The cyclin-dependent kinase (CDK) family plays a critical role in a variety of signaling
pathways that regulate transcription and cell-cycle progression. Recently, the role of CDKs …

Introduction: Cyclin-dependent kinases (CDKs) regulate cell cycle progression. Certain
CDKs (eg, CDK7, CDK9) also control cellular transcription. Consequently, CDKs represent …

DNA damage response, a key factor involved in maintaining genome integrity and stability,
consists of several kinase-dependent signaling pathways, which sense and transduce DNA …

DNA lesions are sensed by a network of proteins that trigger the DNA damage response
(DDR), a signaling cascade that acts to delay cell cycle progression and initiate DNA repair …

Cattleyaks are the crossbred offspring between cattle and yaks, exhibiting the prominent
adaptability to the harsh environment as yaks and much higher growth performances than …

Abstract Topoisomerase 1 (Top1) controls DNA topology, relieves DNA supercoiling during
replication and transcription, and is critical for mitotic progression to the G1 phase. Tyrosyl …

Krüppel-like factor 5 (KLF5) is a pro-proliferative transcriptional regulator primarily
expressed in the intestinal crypt epithelial cells. Constitutive intestine-specific deletion of Klf5 …

The DNA damage sensor Mre11-Rad50-Nbs1 complex and Polo kinase are recruited to
DNA lesions during mitosis. However, their mechanism of recruitment is elusive. Here, using …

Chromosome ends contain nucleoprotein structures known as telomeres. Damage to
chromosome ends during interphase elicits a DNA damage response (DDR) resulting in cell …

Our results demonstrate that the addition of cisplatin after paclitaxel-induced mitotic arrest
was more effective than individual treatment on gastric adenocarcinoma cells (MKN45) …