Synapses are specialized junctions between neurons in brain that transmit and compute
information, thereby connecting neurons into millions of overlapping and interdigitated …

The structure of neuronal circuits that subserve cognitive functions in the brain is shaped
and refined throughout development and into adulthood. Evidence from human and animal …

Epilepsy is a group of disorders characterized by recurrent seizures, and is one of the most
common neurological conditions. The genetic basis of epilepsy is clear from epidemiological …

Epilepsy, a neurological disease characterized by recurrent seizures, is highly
heterogeneous in nature. Based on the prevalence, epilepsy is classified into two types …

AMPA-and NMDA-type glutamate receptors mediate distinct postsynaptic signals that differ
characteristically among synapses. How postsynaptic AMPA-and NMDA-receptor levels are …

Objective To evaluate the role of copy number abnormalities detectable using chromosomal
microarray (CMA) testing in patients with epilepsy at a tertiary care center. Methods We …

NRXN1 undergoes extensive alternative splicing, and non-recurrent heterozygous deletions
in NRXN1 are strongly associated with neuropsychiatric disorders. We establish that human …

The prevailing understanding of generalized epilepsy is shaped by the traditional definition
that “the responsible neuronal discharge takes place, if not throughout the entire grey matter …

Abstract Contactin‐associated protein‐like 2 (CASPR2) is a cell adhesion protein of the
neurexin family. Proteins of this family have been shown to play a role in the development of …

Many neuropsychiatric and neurodevelopmental disorders commonly share genetic risk
factors. To date, the mechanisms driving the pathogenesis of these disorders, particularly …