[HTML][HTML] Tick saliva and the alpha-gal syndrome: finding a needle in a haystack

SR Sharma, S Karim - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
Ticks and tick-borne diseases are significant public health concerns. Bioactive molecules in
tick saliva facilitate prolonged blood-feeding and transmission of tick-borne pathogens to the …

[HTML][HTML] The α-Gal syndrome and potential mechanisms

P Román-Carrasco, W Hemmer, A Cabezas-Cruz… - Frontiers in …, 2021 - frontiersin.org
The α-Gal syndrome is a complex allergic disease characterized by the development of
specific IgE antibodies against the carbohydrate galactose-α-1, 3-galactose (α-Gal), an …

Principles, potential, and limitations of ex vivo basophil activation by flow cytometry in allergology: a narrative review

DG Ebo, CH Bridts, CH Mertens, V Sabato - Journal of Allergy and Clinical …, 2021 - Elsevier
The major challenge of allergy diagnosis lies in the development of accessible and reliable
diagnostics allowing correct prediction of the clinical outcome following exposure to the …

Carbohydrate epitopes currently recognized as targets for IgE antibodies

TA Platts‐Mills, C Hilger, U Jappe, M van Hage… - Allergy, 2021 - Wiley Online Library
Until recently, glycan epitopes have not been documented by the WHO/IUIS Allergen
Nomenclature Sub‐Committee. This was in part due to scarce or incomplete information on …

The meat of the matter: understanding and managing alpha-gal syndrome

JD Macdougall, KO Thomas… - ImmunoTargets and …, 2022 - Taylor & Francis
Alpha-gal syndrome is an unconventional food allergy, characterized by IgE-mediated
hypersensitivity responses to the glycan galactose-alpha-1, 3-galactose (alpha-gal) and not …

Management of food allergies and food-related anaphylaxis

EGA Iglesia, M Kwan, YV Virkud, OI Iweala - JAMA, 2024 - jamanetwork.com
Importance An estimated 7.6% of children and 10.8% of adults have IgE-mediated food-
protein allergies in the US. IgE-mediated food allergies may cause anaphylaxis and death. A …

[HTML][HTML] α-Gal present on both glycolipids and glycoproteins contributes to immune response in meat-allergic patients

N Chakrapani, J Fischer, K Swiontek… - Journal of Allergy and …, 2022 - Elsevier
Background The α-Gal syndrome is associated with the presence of IgE directed to the
carbohydrate galactose-α-1, 3-galactose (α-Gal) and is characterized by a delayed allergic …

[HTML][HTML] The α-Gal epitope-the cause of a global allergic disease

M Perusko, J Grundström, M Eldh, C Hamsten… - Frontiers in …, 2024 - frontiersin.org
The galactose-α-1, 3-galactose (α-Gal) epitope is the cause of a global allergic disease, the
α-Gal syndrome (AGS). It is a severe form of allergy to food and products of mammalian …

[HTML][HTML] Tick bite-induced alpha-gal syndrome and immunologic responses in an alpha-gal deficient murine model

SR Sharma, SK Choudhary, J Vorobiov… - Frontiers in …, 2024 - frontiersin.org
Introduction Alpha-Gal Syndrome (AGS) is a delayed allergic reaction due to specific IgE
antibodies targeting galactose-α-1, 3-galactose (α-gal), a carbohydrate found in red meat …

Flow-based allergen testing: Can mast cells beat basophils?

DG Ebo, K Heremans, M Beyens… - Clinica Chimica …, 2022 - Elsevier
The basophil activation test (BAT) has emerged as a reliable complementary diagnostic to
document IgE-dependent allergies and to study cross-reactivity between structural …