Mineralocorticoid receptor (MR) activation in the heart and vessels leads to pathological
effects, such as excessive extracellular matrix accumulation, oxidative stress, and sustained …

Activation of the mineralocorticoid receptor (MR) in the distal nephron by its ligand,
aldosterone, plays an important role in sodium reabsorption and blood pressure regulation …

Pulmonary hypertension is characterized by progressive remodeling of the pulmonary
arteries, however, this is not therapeutically targeted yet. Aldosterone and the MR …

Numerous mediators and drugs regulate blood flow or arterial pressure by acting on
vascular tone, involving cyclic nucleotide intracellular pathways. These signals lead to …

Activation of the renin–angiotensin–aldosterone system (RAAS) plays an important
pathophysiological role in hypertension. Increased mRNA levels of the angiotensinogen …

Primary aldosteronism (PA) is the most common cause of secondary hypertension. A
growing body of evidence has suggested that, beyond its well-known effects on blood …

Mineralocorticoid receptor activation in endothelial and smooth muscle cells can promote
vascular disease by increasing oxidative stress, promoting inflammation, accelerating …

Dexamethasone is the most clinically used glucocorticoid with an established role in the
treatment of a wide spectrum of inflammatory-related diseases. While the therapeutic actions …

After half a century of evidence suggesting the existence of mineralocorticoid receptors (MR)
in the vasculature, the advent of technology to specifically knockout the MR from smooth …

In mesenteric arteries (MAs), aldosterone (ALDO) binds to the endogenous
mineralocorticoid receptor (MR) and increases the expression of the voltage-gated L-type …