Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and
the subsequent recruitment of chromodomain proteins such as heterochromatin protein …

A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …

The microtubule-binding interface of the kinetochore is of central importance in chromosome
segregation. Although kinetochore components that stabilize, translocate on, and affect the …

Segregation of the replicated genome during cell division in eukaryotes requires the
kinetochore to link centromeric DNA to spindle microtubules. The kinetochore is composed …

Tri-methylation of histone H3 lysine 9 is important for recruiting heterochromatin protein 1
(HP1) to discrete regions of the genome, thereby regulating gene expression, chromatin …

Identification of protein phosphorylation sites with their cognate protein kinases (PKs) is a
key step to delineate molecular dynamics and plasticity underlying a variety of cellular …

Kinetochores are large protein assemblies built on chromosomal loci named centromeres.
The main functions of kinetochores can be grouped under four modules. The first module, in …

In vertebrates, centromeres lack defined sequences and are thought to be propagated by
epigenetic mechanisms involving the incorporation of specialized nucleosomes containing …

Background Gene expression profiling has revolutionized our ability to molecularly classify
primary human tumors and significantly enhanced the development of novel tumor markers …