Current methods for hyperpolarized [1‐13C]pyruvate MRI human studies
PEZ Larson, JML Bernard, JA Bankson… - Magnetic resonance …, 2024 - Wiley Online Library
Abstract MRI with hyperpolarized (HP) 13C agents, also known as HP 13C MRI, can
measure processes such as localized metabolism that is altered in numerous cancers, liver …
measure processes such as localized metabolism that is altered in numerous cancers, liver …
Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate CMR evaluated in an oral glucose challenge
Background The heart has metabolic flexibility, which is influenced by fed/fasting states, and
pathologies such as myocardial ischemia and hypertrophic cardiomyopathy (HCM) …
pathologies such as myocardial ischemia and hypertrophic cardiomyopathy (HCM) …
Cardiac measurement of hyperpolarized 13C metabolites using metabolite‐selective multi‐echo spiral imaging
Purpose Noninvasive imaging with hyperpolarized (HP) pyruvate can capture in vivo cardiac
metabolism. For proper quantification of the metabolites and optimization of imaging …
metabolism. For proper quantification of the metabolites and optimization of imaging …
Probing human heart TCA cycle metabolism and response to glucose load using hyperpolarized [2‐13C]pyruvate MRS
Introduction The healthy heart has remarkable metabolic flexibility that permits rapid
switching between mitochondrial glucose oxidation and fatty acid oxidation to generate ATP …
switching between mitochondrial glucose oxidation and fatty acid oxidation to generate ATP …
Dual‐phase imaging of cardiac metabolism using hyperpolarized pyruvate
Purpose Previous cardiac imaging studies using hyperpolarized (HP)[1‐13C] pyruvate were
acquired at end‐diastole (ED). Little is known about the interaction between cardiac cycle …
acquired at end‐diastole (ED). Little is known about the interaction between cardiac cycle …
Considerations for hyperpolarized 13C MR at reduced field: Comparing 1.5T versus 3T
Purpose In contrast to conventional MR, signal‐to‐noise ratio (SNR) is not linearly
dependent on field strength in hyperpolarized MR, as polarization is generated outside the …
dependent on field strength in hyperpolarized MR, as polarization is generated outside the …
Volumetric Patch-Based Super-Resolution Reconstruction of Hyperpolarized 13C Cardiac MRI
The achievable spatial resolution of 13C metabolic images acquired with hyperpolarized
13C-pyruvate is worse than 1H images typically by an order of magnitude due to the rapidly …
13C-pyruvate is worse than 1H images typically by an order of magnitude due to the rapidly …
[HTML][HTML] Probing Human Heart TCA Cycle Metabolism and Response to Glucose Load using Hyperpolarized [2-13C] Pyruvate MR Spectroscopy
Methods: Good Manufacturing Practice [2-13 C] pyruvic acid was polarized in a 5T polarizer
for 2.5–3 hours. Following dissolution, QC parameters of HP pyruvate met all safety and …
for 2.5–3 hours. Following dissolution, QC parameters of HP pyruvate met all safety and …
[HTML][HTML] Dual hyperpolarized [1-13C] pyruvate and [13C] urea magnetic resonance imaging of prostate cancer
Background Although multiparametric (mp) 1 H magnetic resonance imaging (MRI) is
increasingly used to detect and localize prostate cancer (PC), its correlation with tumor …
increasingly used to detect and localize prostate cancer (PC), its correlation with tumor …
Technical considerations of MRI methods for validating DNP probes in small animals
Probes that are developed for dissolution dynamic nuclear polarization (DNP) should meet
numerous requirements such as solubility, glassing, and spin-lattice relation time, yet only a …
numerous requirements such as solubility, glassing, and spin-lattice relation time, yet only a …