During the past decades, synthetic organic chemistry discovered that directing group
assisted C–H activation is a key tool for the expedient and siteselective construction of C–C …

Conspectus Directing group (DG) assistance provides a good solution to the problems of
reactivity and selectivity, two of the fundamental challenges in C (sp3)–H activation …

In the past decade, multiple catalytic C− H bond functionalization has been successfully
applied in natural product synthesis as a strategy to reduce the number of steps, increase …

Conspectus The catalytic activation and functionalization of unactivated C (sp3)–H bonds of
alkyl groups has undergone intense development in recent years. In particular, a variety of …

Peptide modifications can unlock a variety of compounds with structural diversity and
abundant biological activity. In nature, peptide modifications, such as functionalisation at the …

Improving the reactivity and selectivity is a long pursuing goal in C—H functionalization
reactions. In line with this goal, a well‐designed bidentate 2‐(pyridine‐yl) isopropyl amine …

Given the emerging demand to “escape from flatland” for drug discovery, synthetic methods
that can efficiently construct complex three-dimensional structures with multi-stereocenters …

In recent years, the C–H bond activation field has known very fast expansion offering
valuable synthetic tools. Consequently, the quest for new approaches to afford atom-and …

The development of practical C–H/C–H coupling reactions remains a challenging yet
appealing synthetic venture because it circumvents the need to prefunctionalize both …

Several examples on Pd-catalysed carbonylation of methyl C (sp 3)–H bonds with gaseous
CO via Pd (II)/Pd (0) catalysis have been reported. However, methylene C (sp 3)–H …