A common feature of cancer cells is their ability to rewire their metabolism to sustain the
production of ATP and macromolecules needed for cell growth, division and survival. In …

Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely
applied as a tool for biomarker discovery. Owing to innovative developments in informatics …

Global warming contributes to higher temperatures and reduces rainfall for most areas
worldwide. The concurrent incidence of extreme temperature and water shortage lead to …

Epidemiologic studies have, variably, shown the concomitant use of statin drugs to be
beneficial to cancer outcomes. Statin drugs have been FDA approved for three decades for …

Cancer is a multifaceted global disease. Transformation of a normal to a malignant cell takes
several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming …

Background: Whether statin type influences hepatocellular carcinoma (HCC) incidence or
mortality in chronic hepatitis B or C virus infection is unknown. Objective: To assess the …

Aims: Accurate analysis of dinucleotide redox cofactors nicotinamide adenine dinucleotide
phosphate reduced (NADPH), nicotinamide adenine dinucleotide phosphate (NADP+) …

Statins are associated with delayed fibrosis progression and a reduced risk of hepatocellular
carcinoma (HCC) in chronic hepatitis C virus (HCV). Limited data exist regarding the most …

The pleiotropic benefits of statins in cardiovascular diseases that are independent of their
lipid-lowering effects have been well documented, but the underlying mechanisms remain …

Dysregulated metabolism is a common feature of cancer cells and is considered a hallmark
of cancer. Altered tumor-metabolism confers an adaptive advantage to cancer cells to fulfill …