Decades of research has recognized a solid role for Pim kinases in lymphoproliferative
disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling …

The proviral insertion site in Moloney murine leukemia virus, or PIM proteins, are a family of
serine/threonine kinases composed of three different isoforms (PIM1, PIM2, and PIM3) that …

PIM proteins belong to a family of ser/thr kinases composed of 3 members, PIM1, PIM2 and
PIM3, with greatly overlapping functions. PIM kinases are mainly responsible for cell cycle …

Herein, we report design and synthesis of twenty-one dual PIM-1/HDAC inhibitors utilizing 3-
cyanopyridines as a novel cap moiety linked with aliphatic/aromatic linker bearing carboxylic …

Abstract PIM kinase family (PIM-1, PIM-2 and PIM-3) is an appealing target for the discovery
and development of selective inhibitors, useful in various disease conditions in which these …

Post-translational modifications on the tails of core and linker histones dictate transcription
and have vital roles in disease and development. Acetylation and deacetylation events …

Currently, there is no efficient therapy for patients with peripheral T cell lymphoma (PTCL).
The Proviral Integration site of Moloney murine leukemia virus (PIM) kinases are important …

Despite the success of modern therapy for Hodgkin lymphoma (HL), about 15% of patients
will fail both first-line and second-line therapy and treatment options for these patients are …

OBJECTIVE: To explore the role of proto-oncogene Pim-1 in the proliferation and migration
of nasopharyngeal carcinoma (NPC) cells. METHODS: Pim-1 expressions in NPC cell lines …

Deacetylase (DAC) inhibitors are promising new anticancer drugs that have complex
mechanisms of action, including induction of cell-cycle arrest and apoptosis, inhibition of …