Metabolomic epidemiology offers insights into disease aetiology
Metabolomic epidemiology is the high-throughput study of the relationship between
metabolites and health-related traits. This emerging and rapidly growing field has improved …
metabolites and health-related traits. This emerging and rapidly growing field has improved …
Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases
Y Chen, T Lu, U Pettersson-Kymmer, ID Stewart… - Nature …, 2023 - nature.com
Metabolic processes can influence disease risk and provide therapeutic targets. By
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …
[HTML][HTML] The relationship of circulating choline and choline-related metabolite levels with health outcomes: a scoping review of genome-wide association studies and …
Choline is essential for proper liver, muscle, brain, lipid metabolism, cellular membrane
composition, and repair. Understanding genetic determinants of circulating choline …
composition, and repair. Understanding genetic determinants of circulating choline …
A reference map of potential determinants for the human serum metabolome
The serum metabolome contains a plethora of biomarkers and causative agents of various
diseases, some of which are endogenously produced and some that have been taken up …
diseases, some of which are endogenously produced and some that have been taken up …
Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci
Few studies have explored the impact of rare variants (minor allele frequency< 1%) on
highly heritable plasma metabolites identified in metabolomic screens. The Finnish …
highly heritable plasma metabolites identified in metabolomic screens. The Finnish …
Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine
P Schlosser, N Scherer, F Grundner-Culemann… - Nature …, 2023 - nature.com
The kidneys operate at the interface of plasma and urine by clearing molecular waste
products while retaining valuable solutes. Genetic studies of paired plasma and urine …
products while retaining valuable solutes. Genetic studies of paired plasma and urine …
Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease
We integrated lipidomics and genomics to unravel the genetic architecture of lipid
metabolism and identify genetic variants associated with lipid species putatively in the …
metabolism and identify genetic variants associated with lipid species putatively in the …
Quantifying the contribution of sequence variants with regulatory and evolutionary significance to 34 bovine complex traits
Many genome variants shaping mammalian phenotype are hypothesized to regulate gene
transcription and/or to be under selection. However, most of the evidence to support this …
transcription and/or to be under selection. However, most of the evidence to support this …
Identification of biomarkers to diagnose diseases and find adverse drug reactions by metabolomics
D Saigusa, N Matsukawa, E Hishinuma… - Drug metabolism and …, 2021 - Elsevier
Metabolomics has been widely used for investigating the biological functions of disease
expression and has the potential to discover biomarkers in circulating biofluids or tissue …
expression and has the potential to discover biomarkers in circulating biofluids or tissue …
Metabolic and metabo-clinical signatures of type 2 diabetes, obesity, retinopathy, and dyslipidemia
Macro-and microvascular complications of type 2 diabetes (T2D), obesity, and dyslipidemia
share common metabolic pathways. In this study, using a total of 1,300 metabolites from 996 …
share common metabolic pathways. In this study, using a total of 1,300 metabolites from 996 …