Suspension animal cell culture is now routinely scaled up to bioreactors on the order of
10,000 L, and greater, to meet commercial demand. However, the concern of the 'shear …

Highlights•Animal cell culture producing biopharmaceuticals is a 200 billion dollar
industry.•In thirty years, final product concentrations have risen from 50 mg/L to 25 …

The structure of turbulent motions was measured in a region surrounding the blade tips of a
Rushton turbine mixer. The tip vortices responsible for micromixing were created in this …

The flow and turbulence fields in a fully baffled vessel stirred by a Rushton turbine have
been simulated by means of computational fluid dynamics (CFD) techniques. The simulation …

A microfluidic device was fabricated via photolithographic techniques which can create
transient elongational and shear forces ranging over three orders of magnitude while still …

This study investigated the impact of turbulent heterogeneity in a flocculation reactor on
particle aggregation and breakup. In particular, the influence of average characteristic …

The quantitative description of particle size distribution development in suspension
polymerization reactors is very complex. The exact mechanisms of breakage and …

Multizonal models and, in particular hybrid multizonal/CFD models, represent a powerful
approach to process simulation when complex physical and chemical phenomena (eg …

Different modifications of the Rushton turbine were studied in a dual-impeller agitated tank
(T= 0.4 m), to find the effect of blade form on power draw, turbulent dispersion, gas handling …

Knowledge of particle− liquid mass transfer coefficient (k SL) is important for a rational
design of a solid− liquid/solid− liquid− gas stirred tank reactor (STR). Considerable efforts …