Differential expression of programmed death 1 (PD-1) on various immune cells and its role in human leprosy
Leprosy is a chronic bacterial disease caused by Mycobacterium leprae. Leprosy patients
have been found to have defects in T cells activation, which is critical to the clearance of the …
have been found to have defects in T cells activation, which is critical to the clearance of the …
Interleukin-10 Producing Regulatory B Cells Transformed CD4+CD25− Into Tregs and Enhanced Regulatory T Cells Function in Human Leprosy
Regulatory B cells (Bregs) are known to exhibit their regulatory functions through interleukin-
10 (IL-10) cytokine which suppress inflammation. There are only a few studies explaining …
10 (IL-10) cytokine which suppress inflammation. There are only a few studies explaining …
Calcium-/calmodulin-dependent protein kinase IV (CAMKIV): a multifunctional enzyme and its role in various cancer: an update
The calcium/calmodulin-dependent protein kinase IV (CAMKIV), a multi-functional enzyme,
belongs to the serine/threonine protein kinase family. It plays critical role in inflammatory …
belongs to the serine/threonine protein kinase family. It plays critical role in inflammatory …
Elevated IL-6R on CD4+ T cells promotes IL-6 driven Th17 cell responses in patients with T1R leprosy reactions
Th17 cells play vital role during pathogenesis of leprosy reactions. Previously, we have
reported that IL-23 is involved in Th17 cells differentiation. Subsequently, our group also …
reported that IL-23 is involved in Th17 cells differentiation. Subsequently, our group also …
Neurological features of Hansen disease: a retrospective, multicenter cohort study
X Chen, L Di, M Qian, D Shen, X Feng, X Zhang - Scientific Reports, 2024 - nature.com
To elucidate the neurological features of Hansen disease. The medical records of patients
with confirmed Hansen disease transferred from the neurology department were reviewed …
with confirmed Hansen disease transferred from the neurology department were reviewed …
IL-21 plays an important role in modulating “Th17-treg” cell axis in leprosy type 1 reactions
Leprosy type 1 reaction (T1R) is a cell-mediated inflammatory reaction which involves skin
and peripheral nerves in leprosy. Lesions with T1R have higher production of IL-17 cytokine …
and peripheral nerves in leprosy. Lesions with T1R have higher production of IL-17 cytokine …
Association of IL-10 gene polymorphism with IL-10 secretion by CD4 and T regulatory cells in human leprosy
Leprosy is a chronic bacterial disease caused by Mycobacterium leprae. Cytokines are
known to play vital role as a peacekeeper during inflammatory and other …
known to play vital role as a peacekeeper during inflammatory and other …
γδ T cells are associated with inflammation and immunopathogenesis of leprosy reactions
Background Leprosy reactions appear episodically in leprosy patients, which lead to high
inflammation, morbidity and peripheral nerve damage. The role of Th17 cell has been well …
inflammation, morbidity and peripheral nerve damage. The role of Th17 cell has been well …
Macrophage immunophenotypes in Jorge Lobo's disease and lepromatous leprosy-A comparative study
BM Sasso, AFA Vallarelli, PS Rosa, AFF Belone… - Microbial …, 2024 - Elsevier
Jorge Lobo's disease (JLD) and lepromatous leprosy (LL) share several clinical, histological
and immunological features, especially a deficiency in the cellular immune response …
and immunological features, especially a deficiency in the cellular immune response …
Algorithm design for a cytokine release assay of antigen-specific in vitro stimuli of circulating leukocytes to classify leprosy patients and household contacts
PHF Marçal, MLM de Souza, RS Gama… - Open Forum …, 2022 - academic.oup.com
Background Immunological biomarkers have often been used as a complementary
approach to support clinical diagnosis in several infectious diseases. The lack of …
approach to support clinical diagnosis in several infectious diseases. The lack of …