In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the
limited regenerative capacity of the myocardium, resulting in the formation of a collagen …

Objectives The frontline drug doxorubicin has been used for treating cancer for over 30
years. While providing a cure in select cases, doxorubicin causes toxicity to most major …

Inflammation plays an important role in the pathogenesis of ischemic stroke and other forms
of ischemic brain injury. Increasing evidence suggests that inflammatory response is a …

Signalling by Toll-like receptors (TLRs) involves five adaptor proteins known as MyD88,
MAL, TRIF, TRAM and SARM. Recent insights have revealed additional functions for MyD88 …

Injury caused by oxidative stress occurs in many clinical scenarios involving ischemia and
reperfusion such as organ transplantation, hemorrhagic shock (HS), myocardial infarction …

Cardiovascular disease constitutes a major and increasing health burden in developed
countries. Although treatments have progressed, the development of novel treatments for …

Recent studies suggest that the heart possesses an innate immune system that is intended
to delimit tissue injury, as well as orchestrate homoeostatic responses, within the heart. The …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Myocardial infarction (MI) is the most common cause of cardiac injury, and subsequent
reperfusion further enhances the activation of innate and adaptive immune responses and …

One of the major therapeutic challenges in the arena of interventional cardiology is to design
strategies aimed at reducing myocardial tissue damage after myocardial infarction. In …