An adhesion occurs when two tissues that normally freely move past each other attach via a
fibrous bridge. Abdominal adhesions place a tremendous clinical and financial burden on …

The appropriate anti-adhesive effect of polymers on cells or tissues in the body is one of the
essential requirements of maintaining health and protecting the body from trauma and …

Progressive peritoneal fibrosis affects patients receiving peritoneal dialysis (PD) and has no
reliable treatment. The mechanisms that initiate and sustain peritoneal fibrosis remain …

Chronic kidney disease (CKD) incidence is growing worldwide, with a significant percentage
of CKD patients reaching end-stage renal disease (ESRD) and requiring kidney …

Histone acetylation/deacetylation play an essential role in modifying chromatin structure and
in regulating cell plasticity in eukaryotic cells. Therefore, histone deacetylase (HDAC) …

Uncontrolled extracellular matrix (ECM) production by fibroblasts in response to injury
contributes to fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). Reactive …

Epithelial-to-mesenchymal transition (EMT) occurs in fibrotic diseases affecting the kidney,
liver and lung, and in the peritoneum of patients undergoing peritoneal dialysis. EMT in the …

Peritoneal dialysis (PD) is a form of renal replacement therapy whose repeated use can alter
dialytic function through induction of epithelial–mesenchymal transition (EMT) and fibrosis …

Peritoneal dialysis (PD) is a therapeutic option for the treatment of end‐stage renal disease
and is based on the use of the peritoneum as a semipermeable membrane for the exchange …

1Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, the Netherlands,
2Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, the Netherlands …