Abstract Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied
compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is …

Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …

Neurons require mechanisms to maintain ATP homeostasis in axons, which are highly
vulnerable to bioenergetic failure. Here, we elucidate a transcellular signaling mechanism …

Aging is a progressive disease affecting around 900 million people worldwide, and in recent
years, the mechanism of aging and aging‐related diseases has been well studied …

Extracellular vesicles (EVs) have recently emerged as versatile elements of cell
communication in the nervous system, mediating tissue homeostasis. EVs influence the …

As a type of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases, sirtuin 2
(SIRT2) is predominantly found in the cytoplasm of cells in the central nervous system …

Abstract Sirtuins (SIRT1-SIRT7), a family of nicotinamide adenine dinucleotide (NAD+)-
dependent enzymes, are key regulators of life span and metabolism. In addition to acting as …

Parkinson's disease (PD), the main risk factor of which is age, is one of the most common
neurodegenerative diseases, thus presenting a substantial burden on the health of affected …

Significance: The remarkable geometry of the axon exposes it to unique challenges for
survival and maintenance. Axonal degeneration is a feature of peripheral neuropathies …

Spatiotemporally dynamic microtubule acetylation underlies diverse physiological and
pathological events. Despite its ubiquity, the molecular mechanisms that regulate the sole …