Notch signalling is involved in many aspects of cancer biology, including angiogenesis,
tumour immunity and the maintenance of cancer stem-like cells. In addition, Notch can …

Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …

Alzheimer's disease (AD) is the most common cause of memory impairment and dementia in
the elderly. AD is pathologically characterized by extracellular deposits of beta-amyloid (Aβ) …

One of the most critical pathological features of Alzheimer's disease (AD) is the
accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain …

An increasing body of evidence suggested that intracellular lipid metabolism is dramatically
perturbed in various cardiovascular and neurodegenerative diseases with genetic and …

Notch signaling is involved in cell fate determination and deregulated in human solid
tumors. Hypoxia is an important feature in many solid tumors, which activates hypoxia …

Amyloid beta (Aβ), the hallmark of Alzheimer's Disease (AD), now appears to be deleterious
in its low number aggregate form as opposed to the macroscopic Aβ fibers historically seen …

The molecular investigation of the amyloidoses began in the mid-19th century with the
observation of areas in human tissues obtained at autopsy that were homogeneous and …

Solanezumab (LY2062430) is a humanized monoclonal antibody that binds to the central
region of β-amyloid, a peptide believed to play a key role in the pathogenesis of Alzheimer's …

Cerebrospinal fluid and positron emission tomography biomarkers accurately predict an
underlying Alzheimer's disease (AD) pathology; however, they represent either invasive or …