IgA nephropathy (IgAN) is the most common primary glomerulonephritis, frequently leading
to end-stage renal disease, as there is no disease-specific therapy. IgAN is diagnosed from …

What is the difference between IgA nephropathy and Henoch-Schönlein purpura nephritis?
Henoch-Schönlein purpura nephritis (HSPN) and IgA nephropathy (IgAN) are considered to …

IgA nephropathy (IgAN) is characterized by circulating immune complexes composed of
galactose-deficient IgA1 and a glycan-specific IgG antibody. These immune complexes …

Immunoglobulin A (IgA) nephropathy is the most prevalent form of glomerulonephritis
worldwide. A renal biopsy is required for an accurate diagnosis, as no convenient biomarker …

IgA nephropathy, initially described in 1968 as a kidney disease with glomerular
“intercapillary deposits of IgA-IgG”, has no disease-specific treatment and is a common …

Circulating immune complexes containing aberrantly glycosylated immunoglobulin A (IgA) 1
play a pivotal role in the pathogenesis of IgA nephropathy (IgAN). A portion of IgA1 secreted …

Jacalin, the major protein from the jackfruit (Artocarpus heterophyllus) seeds, is a tetrameric
two-chain lectin (molecular mass 65 kDa) combining a heavy α chain of 133 amino acid …

Interactions of human mesangial cells with IgA and IgA-containing circulating immune
complexes. Background IgA nephropathy (IgAN) is characterized by IgA1-containing …

Rheumatoid factors (RFs), autoantibodies that bind to the Fc portion of IgG, are important in
the immune response. RF-committed B-cells exist in the circulating lymphocyte pool in a …

Objective: To determine if polyvalent IgG is promising therapy for severe IgA nephropathy.
Design: Open prospective cohort study. Setting: Referral nephrology unit. Patients: 11 adult …