Medicinal leeches have been used in health care since before written history, with widely
varying popularity over the centuries. Nowadays, medicinal leech therapy is mainly used in …

Introduction: Blood coagulation factor XII (FXII) is an emerging and potentially safe drug
target, which dysregulation is associated with thrombosis, hereditary angioedema, and …

Herein we report a microscale parallel synthetic approach allowing for rapid access to
libraries of N‐acylated aminotriazoles and screening of their inhibitory activity against factor …

To counteract thrombosis, new safe and efficient antithrombotics are required. We herein
report the design, synthesis, and biological activity of a series of amide-functionalized …

This study presents a novel series of N-acylated 1, 2, 4-triazol-5-amines and 1 H-pyrazol-5-
amines, featuring a pyrazin-2-yl moiety, developed as covalent inhibitors of thrombin. These …

Direct oral anticoagulants (DOACs), which includes thrombin and factor Xa inhibitors, have
emerged as the preferred therapeutics for thrombotic disorders, penetrating a market …

Introduction Atrial fibrillation is the most frequently diagnosed cardiac arrhythmia globally
and is associated with ischemic stroke and heart failure. Patients with atrial fibrillation are …

An automated sample preparation and separation method for the analysis of various
enzyme‐inhibitor combinations using liquid chromatography (LC) coupled to mass …

New antithrombotic drugs are needed to combat thrombosis, a dangerous pathology that
causes myocardial infarction and ischemic stroke. In this respect, thrombin (FIIa) represents …